ReviewInternational journal of molecular sciences2022
The Potential Roles of Myokines in Adipose Tissue Metabolism with Exercise and Cold Exposure.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- 36-Week personalized resistance training improves muscle function and circulating myokines in older women with possible sarcopenic obesity: a randomized clinical trial.BMC geriatrics · 2025Trial
- Extracellular vesicles enriched with mitochondrial components from intermittently cold-exposed adipose tissue drive metabolically active adipose regeneration via miR-296-3p.Materials today. Bio · 2026Article
- Irisin and exercise activate renal anti-aging pathways and enhance survival in young mice: a translational insight into muscle-kidney crosstalk.European journal of translational myology · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Exercise and cold exposure as dual physiological stressors in MASLD: AMPK-mediated metabolic adaptation and interorgan crosstalk.Frontiers in physiology · 2026Review
- Molecular pathways, tissue-specific roles, and therapeutic opportunities in mitochondrial resilience-based strategies for insulin resistance.Frontiers in clinical diabetes and healthcare · 2026Review
- Skeletal Muscle as an Auto-, Para- and Endocrine Organ: The Role of Myokines in Muscle Metabolism and Other Metabolic Organs.Physiological research · 2025Review
- Transcriptomic analysis of muscle and adipose tissues identifies myokines and adipokines contributing to lipid deposition in Taoyuan Black pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics.International journal of molecular sciences · 2024Article
- Organ crosstalk and dysfunction in sepsis.Annals of intensive care · 2024Review
- Review
- Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine.Sports medicine and health science · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise and cold exposure are two stimuli that have been suggested as solely effective to modulate adipose tissue metabolism and improve metabolic health in obese populations. The two primary organs involved in energy metabolism during exercise and/or cold exposure are skeletal muscle and adipose tissue. Adipose tissue can be divided mainly into two types: white adipose tissue (WAT), which primarily stores energy, and brown adipose tissue (BAT), known as the primary source of thermogenesis. The exercise-stimulated release of myokines allows for crosstalk between skeletal muscle and adipose tissue, partially mediating the beneficial effects of exercise. Cold exposure is another trigger for the regulation of myokine secretions, thus increasing adipose tissue metabolism, especially via activation of BAT. Therefore, this has generated the hypothesis that exercise in conjunction with cold exposure might be the optimal regimen to regulate myokine profiles and gain more beneficial health effects. However, to date, human experimental data regarding different exercise (frequency, type, time and intensity) and cold exposure (temperature, time and frequency) patterns are scarce. In this review, we will summarize the current human clinical trials investigating the regulation of myokines induced by exercise combined with cold exposure, to elaborate on the roles of myokines in mediating adipose tissue metabolism.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.