Evidence map›Paper›PMID 36233266›Full record

ArticleInternational journal of molecular sciences2022

Effective Modulation by Lacosamide on Cumulative Inhibition of

Po-Ming Wu, Yu-Ching Lin, Chi-Wu Chiang, Hsin-Yen Cho, Tzu-Hsien Chuang, Meng-Cheng Yu, Sheng-Nan Wu, Yi-Fang Tu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  2. Article
  3. Ion Channels as a Potential Target in Pharmaceutical Designs.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Po-Ming WuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yu-Ching LinDepartment of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chi-Wu ChiangInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Hsin-Yen ChoDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Tzu-Hsien ChuangDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Meng-Cheng YuDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Sheng-Nan WuDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-5208-3253
Yi-Fang TuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-9498-6178
National Cheng Kung University · TWNational Cheng Kung University Hospital · TW

Funding

Ministry of Science and Technology Taiwan MOST-108-2314B-006-094, -110-2314-B-006-049, 110-2314-B-006-056, 111-2314-B-006-082National Cheng Kung University Hospital NCKUH-11102050, NCKUH-11102029
6 · The paper itself

Abstract

The effects of lacosamide (LCS, Vimpat

Indexed as

SodiumSodium ChannelsIonsLacosamideVeratridineIonsLacosamideSodiumSodium ChannelsVeratridinecumulative inhibitioncurrent recoveryhysteresislacosamide (Vimpat®)late Na+ currentpersistent Na+ currenttransient (peak) Na+ currentvoltage-gated Na+ currentwindow Na+ current

Identifiers

PMID36233266
PMCPMC9570249
OpenAlexW4303709804

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.