Evidence map›Paper›PMID 36234713›Full record

ArticleMolecules (Basel, Switzerland)2022

Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine.

Georgia Gogou, Olga S Koutsoni, Panagiotis Stathopoulos, Leandros A Skaltsounis, Maria Halabalaki, Eleni Dotsika

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Georgia GogouLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Olga S KoutsoniLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Panagiotis StathopoulosDivision of Pharmacognosy and Natural Product Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Leandros A SkaltsounisDivision of Pharmacognosy and Natural Product Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Maria HalabalakiDivision of Pharmacognosy and Natural Product Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15784 Athens, Greece.ORCID 0000-0001-5620-0165
Eleni DotsikaLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
National and Kapodistrian University of Athens · GRPasteur Hellenic Institute · GR

Funding

European Regional Development Fund of EE and the Greek National Funds MIS 5134622Greek State and the European Regional Development Fund MIS5028091Nostos Foundation Trust Fund PhD Fellowship
6 · The paper itself

Abstract

The bioactive compounds present in the edible products of the olive tree have been extensively studied and their favorable effects on various disease risk factors have been demonstrated. The aim of this study was to perform a comparative analysis of the anti-leishmanial effects of total phenolic fractions (TPFs) derived from extra virgin olive oil with different phenolic contents and diverse quantitative patterns. Moreover, the present study investigated their association with miltefosine, a standard anti-leishmanial drug, against both extracellular promastigotes and intracellular amastigotes of a viscerotropic and a dermotropic

Indexed as

Antiprotozoal AgentsLeishmania majorAldehydesCyclopentane MonoterpenesIridoidsOlive OilPhenolsPhosphorylcholineReactive Oxygen SpeciesAldehydesAntiprotozoal AgentsCyclopentane MonoterpenesIridoidsmiltefosineoleaceinoleocanthalOlive OilPhenolsPhosphorylcholineReactive Oxygen Speciescombination therapyintracellular amastigotesisobologramleishmaniasisnatural productspromastigotestotal phenolic fraction

Identifiers

PMID36234713
PMCPMC9571123
OpenAlexW4296746283

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.