Evidence map›Paper›PMID 36235641›Full record

ArticleNutrients2022

Myo-Inositol Moderates Glucose-Induced Effects on Human Placental

Oliver C Watkins, Victoria K B Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Hannah E J Yong, Neha Sharma, Sathya Narayanan Patmanathan, Amaury Cazenave-Gassiot, Anne K Bendt, Keith M Godfrey and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Oliver C WatkinsDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0001-8202-6412
Victoria K B Cracknell-HazraDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Reshma Appukuttan PillaiDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Preben SelvamDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Hannah E J YongSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117609, Singapore.ORCID 0000-0002-8814-752X
Neha SharmaDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Sathya Narayanan PatmanathanDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-4501-6351
Amaury Cazenave-GassiotDepartment of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-3050-634X
Anne K BendtSingapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0001-8198-6104
Keith M GodfreyNIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO17 1BJ, UK.ORCID 0000-0002-4643-0618
Rohan M LewisNIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO17 1BJ, UK.
Markus R WenkDepartment of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Shiao-Yng ChanDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID 0000-0002-3530-3023
National University of Singapore · SGAgency for Science, Technology and Research · SGUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

European Union, Erasmus+ Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JPNational Institute for Health Research NF-SI-0515-10042National Research Foundation (Singapore) NRFI2015-05NIHR Southampton Biomedical Research Centre IS-BRC-1215-20004Singapore National Medical Research Council NMRC/CSA-INV/0010/2016; MOH-CSAINV19nov-0002UK Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

Maternal hyperglycemia is associated with disrupted transplacental arachidonic acid (AA) supply and eicosanoid synthesis, which contribute to adverse pregnancy outcomes. Since placental inositol is lowered with increasing glycemia, and since myo-inositol appears a promising intervention for gestational diabetes, we hypothesized that myo-inositol might rectify glucose-induced perturbations in placental AA metabolism. Term placental explants (

Indexed as

Diabetes, GestationalPlacentaArachidonic AcidEthanolaminesFemaleGlucoseHumansInositolPhospholipidsPregnancyPregnancy OutcomeArachidonic AcidEthanolaminesGlucoseInositolPhospholipidsdiabetesLCMSlipidmetabolismpregnancy

Identifiers

PMID36235641
PMCPMC9572372
OpenAlexW4297224631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.