Evidence map›Paper›PMID 36237161›Full record

ReviewCurrent neuropharmacology2023

Resveratrol-Mediated Regulation of Mitochondria Biogenesis-associated Pathways in Neurodegenerative Diseases: Molecular Insights and Potential Therapeutic Applications.

Abdullah Shaito, Maryam Al-Mansoob, Salma M S Ahmad, Mohammad Z Haider, Ali H Eid, Anna Maria Posadino, Gianfranco Pintus, Roberta Giordo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Abdullah ShaitoBiomedical Research Center, College of Medicine, Qatar University, Doha, 2713, Qatar.
Maryam Al-MansoobDepartment of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, 2713, Qatar.
Salma M S AhmadDepartment of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, 2713, Qatar.
Mohammad Z HaiderCollege of Medicine, QU Health, Qatar University, Doha, 2713, Qatar.
Ali H EidDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, 2713, Qatar.
Anna Maria PosadinoDepartment of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy.
Gianfranco PintusDepartment of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy.
Roberta GiordoCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, 505055, United Arab Emirates.
Qatar University · QAMohammed Bin Rashid University of Medicine and Health Sciences · AEUniversity of Sassari · ITUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders include different neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The molecular mechanisms underpinning neurodegenerative disease pathogenesis are still unclear. Nonetheless, there is experimental evidence to demonstrate that the perturbation of mitochondrial function and dynamics play an essential role. In this context, mitochondrial biogenesis, the growth, and division of preexisting mitochondria, by controlling mitochondria number, plays a vital role in maintaining proper mitochondrial mass and function, thus ensuring efficient synaptic activity and brain function. Mitochondrial biogenesis is tightly associated with the control of cell division and variations in energy demand in response to extracellular stimuli; therefore, it may represent a promising therapeutic target for developing new curative approaches to prevent or counteract neurodegenerative disorders. Accordingly, several inducers of mitochondrial biogenesis have been proposed as pharmacological targets for treating diverse central nervous system conditions. The naturally occurring polyphenol resveratrol has been shown to promote mitochondrial biogenesis in various tissues, including the nervous tissue, and an ever-growing number of studies highlight its neurotherapeutic potential. Besides preventing cognitive impairment and neurodegeneration through its antioxidant and anti-inflammatory properties, resveratrol has been shown to be able to enhance mitochondria biogenesis by acting on its main effectors, including PGC-1α, SIRT1, AMPK, ERRs, TERT, TFAM, NRF-1 and NRF-2. This review aims to present and discuss the current findings concerning the impact of resveratrol on the machinery and main effectors modulating mitochondrial biogenesis in the context of neurodegenerative diseases.

Indexed as

Neurodegenerative DiseasesAntioxidantsHumansMitochondriaNeuronsOrganelle BiogenesisResveratrolAntioxidantsResveratrolcentral nervous systemmitochondriamitochondrial biogenesisneurodegenerative diseasespolyphenolsResveratrol

Identifiers

PMID36237161
PMCPMC10286596
OpenAlexW4306160713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.