Evidence map›Paper›PMID 36237442›Full record

ArticleBiochemistry and biophysics reports2022

PRMT1 is an important factor for medulloblastoma cell proliferation and survival.

Xiao Gu, Miao He, Timofey Lebedev, Cheng-Han Lin, Zhong-Yan Hua, Y George Zheng, Zhi-Jie Li, Jer-Yen Yang, Xing-Guo Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Xiao GuDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Miao HeDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Timofey LebedevDepartment of Cancer Cell Biology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Cheng-Han LinResearch Center for Cancer Biology, Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung City, 406040, Taiwan.
Zhong-Yan HuaDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Y George ZhengDepartment of Pharmaceutical and Biochemical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.
Zhi-Jie LiLiaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.
Jer-Yen YangResearch Center for Cancer Biology, Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung City, 406040, Taiwan.
Xing-Guo LiDepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
University of Rochester · USChina Medical University · CNEngelhardt Institute of Molecular Biology · RUUniversity of Georgia · US

Funding

Mechanism and Inhibition of Protein Arginine MethylationR01GM126154 · NIGMS · UNIVERSITY OF GEORGIA · PI ZHENG, Y. GEORGE · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM126154
6 · The paper itself

Abstract

Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored

Indexed as

Diamidine compoundsDox, DoxycyclineMedulloblastomaPRMT1PRMT1 inhibitorsPRMT1, protein arginine methyltransferase 1shRNA, short hairpin RNA

Identifiers

PMID36237442
PMCPMC9550604
OpenAlexW4303033928

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.