Evidence map›Paper›PMID 36238255›Full record

ArticleFrontiers in public health2022

Tolerance for three commonly administered COVID-19 vaccines by healthcare professionals.

Stacy E F Melanson, Zhen Zhao, Attila Kumanovics, Tanzy Love, Qing H Meng, Alan H B Wu, Fred Apple, Caitlin R Ondracek, Karen M Schulz, Joseph R Wiencek and 3 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stacy E F MelansonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, United States.
Zhen ZhaoDepartment of Laboratory Medicine and Pathology, Weill Cornell Medicine, New York, NY, United States.
Attila KumanovicsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Tanzy LoveDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, United States.
Qing H MengDepartment of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Alan H B WuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
Fred AppleDepartment of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center, Minneapolis, MN, United States.
Caitlin R OndracekAmerican Association for Clinical Chemistry, Washington, DC, United States.
Karen M SchulzHennepin Healthcare Research Institute, Minneapolis, MN, United States.
Joseph R WiencekDepartment of Pathology, Microbiology and Immunology, Vanderbilt School of Medicine, Nashville, TN, United States.
David KochDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
Robert ChristensonDepartment of Pathology, University of Maryland, Baltimore, MD, United States.
Y Victoria ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, United States.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

Importance: Most healthcare institutions require employees to be vaccinated against SARS-CoV-2 and many also require at least one booster. Objective: We determine the impact of vaccine type, demographics, and health conditions on COVID-19 vaccine side effects in healthcare professionals. Design: A COVID-19 immunity study was performed at the 2021 American Association for Clinical Chemistry Annual Scientific meeting. As part of this study, a REDCap survey with cascading questions was administered from September 9, 2021 to October 20, 2021. General questions included participant demographics, past and present health conditions, smoking, exercise, and medications. COVID-19 specific questions asked about SARS-CoV-2 vaccine status and type, vaccine-associated side effects after each dose including any boosters, previous infection with COVID-19, diagnostic testing performed, and type and severity symptoms of COVID-19. Results: There were 975 participants (47.1% male, median age of 50 years) who completed the survey. Pfizer was the most commonly administered vaccine (56.4%) followed by Moderna (32.0%) and Johnson & Johnson (7.1%). There were no significant differences in vaccine type received by age, health conditions, smoking, exercise, or type or number of prescription medications. Side effects were reported more frequently after second dose (e.g., Moderna or Pfizer) (54.1%) or single/only dose of Johnson & Johnson (47.8%). Males were significantly more likely to report no side effects ( Conclusions and relevance: Younger people, females, and those receiving the second dose of Moderna had more COVID-19 vaccine side effects that per self-report led to moderate to severe limitations. As reported in other studies, the increase in side effects from Moderna may be explained by higher viral mRNA concentrations but be associated with additional protective immunity.

Indexed as

COVID-19COVID-19 VaccinesDelivery of Health CareFemaleHumansMaleMiddle AgedSARS-CoV-2VaccinesCOVID-19 VaccinesVaccinesCOVID-19Johnson and JohnsonModernaPfizerSARS-CoV-2side effectsvaccine

Identifiers

PMID36238255
PMCPMC9553122

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.