Evidence map›Paper›PMID 36238685›Full record

ArticleFrontiers in cell and developmental biology2022

KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood.

Marie-Albane Minati, Mohamad Assi, Maxime Libert, Sabine Cordi, Frédéric Lemaigre, Patrick Jacquemin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. SystemicProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. KRAS4B is required for placental development.Cellular and molecular life sciences : CMLS · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marie-Albane MinatiUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
Mohamad AssiUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
Maxime LibertUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
Sabine CordiUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
Frédéric LemaigreUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
Patrick JacqueminUniversité catholique de Louvain, de Duve Institute, Liver and Pancreas Differentiation Unit, Brussels, Belgium.
de Duve Institute · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KRAS mutants are common in many cancers and wild-type KRAS is essential in development as its absence causes embryonic lethality. Despite this critical role in development and disease, the normal expression pattern of KRAS protein is still largely unknown at the tissue level due to the lack of valid antibodies. To address this issue, we used the

Indexed as

developmentepithelial cellsKRASmesenchymal cellsmouse models

Identifiers

PMID36238685
PMCPMC9551567
OpenAlexW4297312263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.