Trial reportObesity (Silver Spring, Md.)2023
The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.
Trial report in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03241121 (Study of Eating Patterns With a Smartphone App and the Metabolic Effects of Time Restricted Feeding), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Eating Patterns With a Smartphone App and the Metabolic Effects of Time Restricted Feeding (TRF) in the Metabolic Syndrome - An Open-label Randomized Controlled Trial of TRF vs Regular Dietary Advices
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Effectiveness and safety of intermittent fasting on blood pressure in adults with overweight or obesity: a systematic review.International journal of obesity (2005) · 2025Pooled it
- Pooled it
- The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.Obesity (Silver Spring, Md.) · 2023Trial
- Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone-Muscle Unit, and Research Priorities.Metabolites · 2026Review
- The diversity and consistency of what and when people eat.Nature metabolism · 2026Article
- Bone Health Following Lifestyle-Induced Weight Loss in Individuals With Overweight/Obesity: A Narrative Review.Obesity (Silver Spring, Md.) · 2026Review
- Effects of timing and eating duration of time restricted eating on metabolic outcomes: systematic review and network meta-analysis.BMJ medicine · 2026Article
- Intermittent fasting alleviates obesity-associated impairments in bone fracture healing: Exploring the role of gut microbiome.Bone reports · 2025Article
- The Effects of Obesity and Weight Loss Interventions on Bone Health: A Narrative Review.Current diabetes reports · 2025Review
- The diversity and consistency of what and when people eat.Research square · 2025Article
- Application of circadian rhythm in osteoporosis prevention and treatment: from light, diet, and exercise to chronotherapy.Frontiers in endocrinology · 2025Review
- Associations between temporal eating patterns and body composition in young adults: a cross-sectional study.European journal of nutrition · 2024Article
- Intermittent fasting and bone health: a bone of contention?The British journal of nutrition · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.
methodsAdults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.
resultsIn the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.
conclusionsTRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.