ArticleJournal of Parkinson's disease2022
Body-First Subtype of Parkinson's Disease with Probable REM-Sleep Behavior Disorder Is Associated with Non-Motor Dominant Phenotype.
Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
- Cholinergic degeneration in prodromal and early Parkinson's disease: a link to present and future disease states.Brain : a journal of neurology · 2026Article
- Progression ofFrontiers in aging neuroscience · 2026Article
- Constipation in a Large Online Cohort of Persons with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- MRI structural and functional axial asymmetry in the brain-first versus body-first subtypes of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Four questions to predict cognitive decline in de novo Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Plasma GFAP and NfL associate with cerebral glucose metabolism in putative brain-first and body-first Parkinson's disease subtypes.NPJ Parkinson's disease · 2025Article
- Orthostatic Hypotension: a clinical marker for the body-first subtype of patients with Parkinson's Disease.NPJ Parkinson's disease · 2024Article
- Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Disease progression in proposed brain-first and body-first Parkinson's disease subtypes.NPJ Parkinson's disease · 2024Article
- Cognition and Other Non-Motor Symptoms in an At-Risk Cohort for Parkinson's Disease Defined by REM-Sleep Behavior Disorder and Hyposmia.Journal of Parkinson's disease · 2024Article
- Parkinson's Disease and Dementia with Lewy Bodies: One and the Same.Journal of Parkinson's disease · 2024Review
- REM Behavior Disorder: Implications for PD Therapeutics.Current neurology and neuroscience reports · 2023Review
- Luxembourg Parkinson's study -comprehensive baseline analysis of Parkinson's disease and atypical parkinsonism.Frontiers in neurology · 2023Article
- Multifactorial assessment of Parkinson's disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort - extension of the LONG-PD study.Frontiers in aging neuroscience · 2023Article
- Minor hallucinations in Parkinson's disease with probable rapid eye movement sleep behavior disorder.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe hypothesis of body-first vs. brain-first subtype of PD has been proposed with REM-Sleep behavior disorder (RBD) defining the former. The body-first PD presumes an involvement of the brainstem in the pathogenic process with higher burden of autonomic dysfunction.
objectiveTo identify distinctive clinical subtypes of idiopathic Parkinson's disease (iPD) in line with the formerly proposed concept of body-first vs. brain-first subtypes in PD, we analyzed the presence of probable RBD (pRBD), sex, and the APOEɛ4 carrier status as potential sub-group stratifiers.
methodsA total of 400 iPD patients were included in the cross-sectional analysis from the baseline dataset with a completed RBD Screening Questionnaire (RBDSQ) for classifying as pRBD by using the cut-off RBDSQ≥6. Multiple regression models were applied to explore (i) the effect of pRBD on clinical outcomes adjusted for disease duration and age, (ii) the effect of sex on pRBD, and (iii) the association of APOEɛ4 and pRBD.
resultsiPD-pRBD was significantly associated with autonomic dysfunction (SCOPA-AUT), level of depressive symptoms (BDI-I), MDS-UPDRS I, hallucinations, and constipation, whereas significantly negatively associated with quality of life (PDQ-39) and sleep (PDSS). No significant association between sex and pRBD or APOE ɛ4 and pRBD in iPD was found nor did we determine a significant effect of APOE ɛ4 on the PD phenotype.
conclusionWe identified an RBD-specific PD endophenotype, characterized by predominant autonomic dysfunction, hallucinations, and depression, corroborating the concept of a distinctive body-first subtype of PD. We did not observe a significant association between APOE ɛ4 and pRBD suggesting both factors having an independent effect on cognitive decline in iPD.
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