Evidence map›Paper›PMID 36246729›Full record

ArticleClinical and translational allergy2022

The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland.

Sanna Toppila-Salmi, Jenni Hällfors, Juhani Aakko, Bettina Mannerström, Kaisa Nieminen, Gunilla Telg, Lauri Lehtimäki

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Tissue eosinophilia suggests dupilumab treatment response in chronic rhinosinusitis with nasal polyps (CRSwNP).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Review
  4. Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps: An Observational Cohort Study Using Swedish Register Data.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025
    Observational
  5. The value of treatable traits across the spectrum of adult asthma severity.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  6. Causal role of MiRNAs in chronic rhinosinusitis: mendelian randomization and validation study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Article
  7. A Study to Compare the Relationship Between Tissue Eosinophilia and Radiological Findings in Nasal Polyposis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Asthma is Underdiagnosed and Often Uncontrolled in Preoperative Patients With Chronic Rhinosinusitis With Nasal Polyps.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024
    Article
  12. The use of biologics in patients suffering from chronic rhinosinusitis with nasal polyps - a 4-year real life observation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Observational
  13. Comorbidities of chronic rhinosinusitis in children and adults.Clinical and translational allergy · 2024
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sanna Toppila-SalmiDepartment of Allergology Department of Pulmonary Medicine, Heart and Lung Center Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland.ORCID https://orcid.org/0000-0003-0890-6686
Jenni HällforsMedaffcon Oy Espoo Finland.
Juhani AakkoMedaffcon Oy Espoo Finland.ORCID https://orcid.org/0000-0003-4142-3256
Bettina MannerströmMedaffcon Oy Espoo Finland.ORCID https://orcid.org/0000-0001-9316-5581
Kaisa NieminenAstraZeneca Nordic Espoo Finland.
Gunilla TelgAstraZeneca Nordic Södertälje Sweden.
Lauri LehtimäkiFaculty of Medicine and Health Technology Tampere University Respiratory Research Group Tampere University Tampere Finland.
AstraZeneca (Finland) · FIAstraZeneca (Sweden) · SETampere University · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly associated with asthma. Treatment of CRSwNP includes intranasal and systemic corticosteroids, with non-responsive patients commonly considered for endoscopic sinus surgery (ESS). This nationwide register-based study evaluated the incidence, prevalence, and treatment burden of CRSwNP in Finland, and their association with the presence and severity of comorbid asthma. Methods: Electronic health records of patients diagnosed with CRSwNP between 1.1.2012 and 31.12.2018 in Finnish specialty and primary care were included in the study. The patients were divided into subgroups based on presence, severity, and control of asthma: no asthma, mild to moderate asthma, severe controlled asthma, and severe uncontrolled asthma. A mean cumulative count of ESS was calculated over time per subgroup. Results: The prevalence of CRSwNP increased from 602.2 to 856.7 patients per 100,000 population between years 2012 and 2019 ( Conclusions: The prevalence of CRSwNP showed a significant increase in the recent decade in Finland. Comorbid asthma, and in particular severe asthma, increased the probability of receiving systemic corticosteroids and undergoing ESS. Thus, improved management of CRSwNP in patients with comorbid asthma is urgently needed.

Indexed as

asthmacomorbidityCRSwNPendoscopic sinus surgerynasal polyps

Identifiers

PMID36246729
PMCPMC9549071
OpenAlexW4303983082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.