Evidence map›Paper›PMID 36246995›Full record

ArticleDialogues in clinical neuroscience2022

Cardiac vagal activity is associated with gut-microbiome patterns in women-An exploratory pilot study.

Sabrina Mörkl, Andreas Oberascher, Josef M Tatschl, Sonja Lackner, Thomaz F S Bastiaanssen, Mary I Butler, Maximilian Moser, Matthias Frühwirth, Harald Mangge, John F Cryan and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Dialogues in clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  9. Review
  10. The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications.Journal of neurogastroenterology and motility · 2023
    Review
  11. Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis.International journal of clinical and health psychology : IJCHP
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sabrina MörklDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.ORCID 0000-0001-5034-6358
Andreas OberascherDepartment of Psychiatry, Psychotherapy and Psychosomatics, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Josef M TatschlHealth Psychology Unit, University of Graz, Graz, Austria.ORCID 0000-0003-1594-1770
Sonja LacknerDivision of Immunology and Pathophysiology, Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Medical University of Graz, Graz, Austria.ORCID 0000-0002-5002-4460
Thomaz F S BastiaanssenAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0001-6891-734X
Mary I ButlerAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Maximilian MoserDivision of Physiology, Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Medical University of Graz, Graz, Austria.ORCID 0000-0001-9292-5091
Matthias FrühwirthHuman Research Institute of Health Technology and Prevention Research, Weiz, Austria.
Harald ManggeClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.ORCID 0000-0003-4067-247X
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0001-5887-2723
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-2316-7220
Sandra J HolasekDivision of Immunology and Pathophysiology, Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Medical University of Graz, Graz, Austria.ORCID 0000-0002-2958-3516
Medical University of Graz · ATUniversity College Cork · IEUniversity of Graz · ATUniversity of Salzburg · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A functional reciprocity between the gut microbiome and vagal nerve activity has been suggested, however, human studies addressing this phenomenon are limited. Methods: Twenty-four-hour cardiac vagal activity (CVA) was assessed from 73 female participants (aged 24.5 ± 4.3 years). Additionally, stool samples were subjected to 16SrRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyse microbiome data. Additionally, inflammatory parameters (such as CRP and IL-6) were derived from serum samples. Results: Daytime CVA correlated significantly with gut microbiota diversity ( Conclusions: As an indicator of gut-brain communication, gut microbiome analysis could be extended by measurements of CVA to enhance our understanding of signalling

Indexed as

Gastrointestinal MicrobiomeMicrobiotaFemaleHumansInterleukin-6Pilot ProjectsInterleukin-6autonomic nervous systemgut-brain-axisGut microbiotaheart rate variabilityvagal nerve

Identifiers

PMID36246995
PMCPMC9559470
OpenAlexW4304182496

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.