ArticleAnimal reproduction
Impact of thermal stress on placental function and fetal physiology.
Article in Animal reproduction. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- A systematic review and meta-analysis of heat exposure impacts on maternal, fetal and neonatal health.Nature medicine · 2025Pooled it
- Universal Thermal Climate Index and Gestational Diabetes Mellitus Risk: Effect Modification by Green Space in a Chinese Prospective Cohort.BMC public health · 2026Article
- Intersection of Climate and Environmental Change and Priority Health Outcomes Across the Life Course: Working Group 1 Report from the "Agriculture and Diet: Value Added for Nutrition, Translation, and Adaptation in a Global Ecology" (ADVANTAGE) Project.Advances in nutrition (Bethesda, Md.) · 2026Review
- Mechanistic understanding of heat stress in cattle reproduction toward pharmacological strategies: review.Animal bioscience · 2026Article
- Sex-specific placental adaptations associated with fetal growth restriction: a review.Journal of animal science · 2026Review
- Severe claw lesions in pregnant sows reduce prolificacy and increase litter heterogeneity.Porcine health management · 2025Article
- Extreme temperature events exposure and risks of stillbirths: nationwide large birth cohort study in China.Environment international · 2025Article
- Article
- Fetal programming under maternal heat stress: a focus on skeletal muscle growth and nutrition in livestock.Journal of developmental origins of health and disease · 2025Review
- Cohort Profile for the Heat in Pregnancy- India (HiP-India) Study.Wellcome open research · 2025Article
- Impact of Heat on Birth Outcomes and Child Nutrition: Study Protocol using the CIDACS Birth Cohort.Wellcome open research · 2025Article
- Thermal Comfort Conditions and Mortality in Brazil.International journal of environmental research and public health · 2024Article
- Mitochondrial respiration is lower in the intrauterine growth-restricted fetal sheep heart.The Journal of physiology · 2024Article
- Critical Windows of Maternal Exposure to Biothermal Stress and Birth Weight for Gestational Age in Western Australia.Environmental health perspectives · 2023Article
- Article
- Increasing global temperatures threaten gains in maternal and newborn health in Africa: A review of impacts and an adaptation framework.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Review
- Placental Development and Physiological Changes in Pregnant Ewes in Silvopastoral and Open Pasture Systems during the Summer.Animals : an open access journal from MDPI · 2023Article
- Daily injection of the β2 adrenergic agonist clenbuterol improved poor muscle growth and body composition in lambs following heat stress-induced intrauterine growth restriction.Frontiers in physiology · 2023Article
- Sexual dimorphic gene expression profile of perirenal adipose tissue in ovine fetuses with growth restriction.Frontiers in physiology · 2023Article
- Maternal nutritional status modifies heat-associated growth restriction in women with chronic malnutrition.PNAS nexus · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In ruminants, prolonged exposure to high ambient temperatures negatively affects placental development and function. The pursuing limitations in placental oxygen and nutrient supply between the mother and fetus slow fetal growth lowering birth weights and postnatal performance. The pregnant ewe is a long-standing animal model for the study of maternal- fetal interactions and is susceptible to naturally occurring heat stress, which causes fetal growth restriction. In the pregnant ewe, studies show that the fetus adapts to hyperthermia-induced placental insufficiency to preserve placental transport capacity of oxygen and nutrients. These adaptive responses are at the expense of normal fetal development and growth. Enlarged transplacental gradient for oxygen and glucose facilitates diffusion across the placenta, but develops by lowering fetal blood oxygen and glucose concentrations. Fetal hypoxemia and hypoglycemia slow growth and alter their metabolic and endocrine profiles. Deficits in amino acids transport across the placenta are present but are overcome by reduced fetal clearance rates, likely due to fetal hypoxemia or endocrine responses to hypoxic stress. Here, we provide an overview of the performance limitations observed in ruminants exposed to heat stress during pregnancy, but we focus our presentation on the sheep fetus in pregnancies complicated by hyperthermia-induced placental insufficiency. We define the characteristics of placental dysfunction observed in the fetus of heat stressed ewes during pregnancy and present developmental adaptations in organogenesis, metabolism, and endocrinology that are proposed to establish maladaptive situations reaching far beyond the perinatal period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.