Evidence map›Paper›PMID 36255253›Full record

ArticleAntimicrobial agents and chemotherapy2022

Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite.

Ishrya Sharma, Laura Farr, Shannon Moonah

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ishrya SharmaDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.
Laura FarrDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.
Shannon MoonahDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.ORCID 0000-0001-7376-5125
University of Virginia · US

Funding

Disulfiram for Entameoba histolytica Enteric Diarrhea [DEED] TrialR34AI165304 · NIAID · UNIVERSITY OF VIRGINIA · PI WARREN, CIRLE ALCANTARA · 2022 to 2022
$244k
NIAID NIH HHS R34 AI165304
6 · The paper itself

Abstract

New anti-Entamoeba histolytica multistage drugs are needed because only one drug class, nitroimidazoles, is available for treating invasive disease, and it does not effectively eradicate the infective cyst stage. Zinc ditiocarb (ZnDTC), a main metabolite of the FDA-approved drug disulfiram, was recently shown to be highly effective against the invasive trophozoite stage. In this brief report, we show that ZnDTC is active against cysts, with similar potency to first-line cysticidal drug paromomycin.

Indexed as

AlcoholismCystsEntamoeba histolyticaParasitesAnimalsDisulfiramDitiocarbDisulfiramDitiocarbdisulfiramdrug developmentdrug repurposingEntamoeba histolyticaprotozoan parasites

Identifiers

PMID36255253
PMCPMC9664845
OpenAlexW4306731461

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.