Evidence map›Paper›PMID 36258233›Full record

Trial reportNutrition journal2022

Effects of a high-fat meal on inflammatory and endothelial injury biomarkers in accordance with adiposity status: a cross-sectional study.

Maria das Graças Coelho de Souza, Priscila Alves Maranhão, Diogo Guarnieri Panazzolo, José Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01692327 (Evaluating the Effect of Lipid Overload in Endothelial Function and Microvascular Reactivity in Young Obese Women), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01692327 nacompletednot on this map

Evaluating the Effect of Lipid Overload in Endothelial Function and Microvascular Reactivity in Young Obese Women

TypeinterventionalSponsorRio de Janeiro State UniversityRan2012 to 2014Enrolled60ConditionsObesityArmsHigh fat meal
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Maria das Graças Coelho de SouzaLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
Priscila Alves MaranhãoLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
Diogo Guarnieri PanazzoloLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
José Firmino Nogueira NetoLipids Laboratory (Lablip), State University of Rio de Janeiro (UERJ), Policlínica Piquet Carneiro, 20550-003, Rio de Janeiro, RJ, Brazil.
Eliete BouskelaLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil.
Luiz Guilherme Kraemer-AguiarLaboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro (UERJ), 20550- 013, Rio de Janeiro, RJ, Brazil. lgkraemeraguiar@gmail.com.
Universidade do Estado do Rio de Janeiro · BRHospital Universitário Pedro Ernesto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is known that consuming a high-fat meal (HFM) induces microvascular dysfunction (MD) in eutrophic women and aggravates it in those with obesity. Our purpose was to investigate if the MD observed after a single HFM intake is caused by endothelial damage or increased inflammatory state, both determined by blood biomarkers.

methodsNineteen women with obesity (BMI 30-34.9 kg/m

resultsLevels of soluble E-selectin, leptin, and PAI-1 were higher in OBG at all-time points (P < 0.05) compared to CG. In the fasting state, OBG had higher levels of NEFA compared to CG (P < 0.05). In intra-group analysis, no significant change in the levels of circulating inflammatory and endothelial injury biomarkers was observed after HFM intake, independently of the group.

conclusionOur findings suggest that women with obesity have an increased pro-inflammatory state and more significant endothelial injury compared to eutrophic ones. However, the consumption of a HFM was not sufficient to change circulating levels of inflammatory and endothelial injury biomarkers in either group. REGISTRATION NUMBER FOR CLINICAL TRIALS: NCT01692327.

Indexed as

AdiposityLeptinAdipokinesAdiponectinBiomarkersCross-Sectional StudiesEndothelium, VascularE-SelectinFatty Acids, NonesterifiedFemaleHumansIntercellular Adhesion Molecule-1Interleukin-6ObesityPlasminogen Activator Inhibitor 1Tumor Necrosis Factor-alphaAdipokinesAdiponectinBiomarkersE-SelectinFatty Acids, NonesterifiedIntercellular Adhesion Molecule-1Interleukin-6LeptinPlasminogen Activator Inhibitor 1Tumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1EndotheliumHigh fat mealInflammationObesityPostprandial period

Identifiers

PMID36258233
PMCPMC9580189
OpenAlexW4306742324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.