ArticlePlant communications2022
OPAQUE3, encoding a transmembrane bZIP transcription factor, regulates endosperm storage protein and starch biosynthesis in rice.
Article in Plant communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 70 citations in OpenAlex.
- OsbZIP60 Positively Regulates Salt-Stress Tolerance in Rice.International journal of molecular sciences · 2026Article
- Transcriptional networks shaping malting quality in barley: From grain development to brewing performance.Food chemistry. Molecular sciences · 2026Review
- Discovering of the transcriptional regulatory network involved in starch biosynthesis in sorghum grains.Plant diversity · 2026Article
- Genetic Determinants and Breeding Strategies for Rice Cooking and Eating Quality: A Comprehensive Review.Plant biotechnology journal · 2026Review
- The OsMADS18-OsbZIP60 module plays a critical role in influencing grain chalkiness in rice.Science China. Life sciences · 2026Article
- Regulation of grain protein content by the amino acid permease gene OsAAP4 in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Modification of starch synthesis in food crops using CRISPR/Cas9 gene editing technology for changing climate.Stress biology · 2026Review
- Nitrogen Topdressing Rate Alters Starch and Protein Properties in Grains at Different Spike Positions Under Long-Term Field Conditions.Plants (Basel, Switzerland) · 2025Article
- A glutamyl-tRNA reductase and its binding protein promote transitory starch biosynthesis and enhance grain quality and yield in rice.Plant communications · 2025Article
- A Natural Major Module Confers the Trade-Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Overexpression of thePlants (Basel, Switzerland) · 2025Article
- Article
- The bZIP transcription factor RISBZ1 balances grain filling and ER stress response in rice grains.Plant communications · 2025Article
- Functional Analysis of the Autophagy-Related GenePlants (Basel, Switzerland) · 2025Article
- The F-box protein CHALK10 mediates SEMIDWARF-1 ubiquitination and degradation to negatively regulate grain chalkiness in rice.Plant communications · 2025Article
- A large-scale gene regulatory network for rice endosperm starch biosynthesis and its application in genetic improvement of rice quality.Plant biotechnology journal · 2025Article
- A MYB61-SWB9-KOs module regulates grain chalkiness via gibberellin biosynthesis in rice endosperm.Plant biotechnology journal · 2025Article
- Article
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- OsSPL14 and OsNF-YB9/YC8-12 subunits cooperate to enhance grain appearance quality by promoting Waxy and PDIL1-1 expression in rice.Plant communications · 2025Article
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15 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Starch and storage proteins are the main components of rice (Oryza sativa L.) grains. Despite their importance, the molecular regulatory mechanisms of storage protein and starch biosynthesis remain largely elusive. Here, we identified a rice opaque endosperm mutant, opaque3 (o3), that overaccumulates 57-kDa proglutelins and has significantly lower protein and starch contents than the wild type. The o3 mutant also has abnormal protein body structures and compound starch grains in its endosperm cells. OPAQUE3 (O3) encodes a transmembrane basic leucine zipper (bZIP) transcription factor (OsbZIP60) and is localized in the endoplasmic reticulum (ER) and the nucleus, but it is localized mostly in the nucleus under ER stress. We demonstrated that O3 could activate the expression of several starch synthesis-related genes (GBSSI, AGPL2, SBEI, and ISA2) and storage protein synthesis-related genes (OsGluA2, Prol14, and Glb1). O3 also plays an important role in protein processing and export in the ER by directly binding to the promoters and activating the expression of OsBIP1 and PDIL1-1, two major chaperones that assist with folding of immature secretory proteins in the ER of rice endosperm cells. High-temperature conditions aggravate ER stress and result in more abnormal grain development in o3 mutants. We also revealed that OsbZIP50 can assist O3 in response to ER stress, especially under high-temperature conditions. We thus demonstrate that O3 plays a central role in rice grain development by participating simultaneously in the regulation of storage protein and starch biosynthesis and the maintenance of ER homeostasis in endosperm cells.
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