ArticleCureus2022
A Rare Case of HIV-Induced Neutropenia Resulting in Haemophilus influenzae Septic Oligoarthritis: A Case-Based Literature Review.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Septic arthritis is a medical emergency that rarely occurs without direct trauma to a joint, compromise or trauma to the synovium, or internal hematogenous seeding from bacteremia. Infection of a single joint space is a cause for concern, and infection of multiple joints is even more rare and concerning. Human immunodeficiency virus (HIV) renders patients particularly susceptible to encapsulated bacteria as it compromises opsonization, humoral immunity, as well as neutrophil function. Neutrophils play an important role in preventing and fighting off infections of the synovium, and it is well documented that compromised neutrophil function can result in this peculiar infection. HIV is popularly acknowledged for its suppression of the lymphoid division of the immune system, particularly CD4 T-cells suppression. However, HIV's effects on myeloid cells are largely overlooked in medical academia, specifically with respect to neutrophil dysfunction. We will explore a case where compromised neutrophil function results in rare infiltration of
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