Evidence map›Paper›PMID 36263097›Full record

ArticleBioactive materials2023

A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis.

Yibo Ying, Zhiyang Huang, Yurong Tu, Qiuji Wu, Zhaoyu Li, Yifan Zhang, Huilei Yu, Annian Zeng, Hanzhi Huang, Jiahui Ye and 7 more

Abstract read
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Review
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  11. Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Human dental pulp stem cells for spinal cord injury.Stem cell research & therapy · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yibo YingSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Zhiyang HuangSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Yurong TuSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Qiuji WuSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Zhaoyu LiDepartment of Overseas Education College, Jimei University, Xiamen, Fujian, China.
Yifan ZhangSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Huilei YuSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Annian ZengSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Hanzhi HuangSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Jiahui YeSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Weiyang YingSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Min ChenSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Zhiyi FengSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Ziyue XiangSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Qingsong YeCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, 460030, Hubei, China.
Sipin ZhuSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Zhouguang WangSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing it to match the physical properties of the spinal cord; additionally, this hydrogel scavenges ROS well, allowing it to inhibit the lipid peroxidation caused by ferroptosis. According to the

Indexed as

Dental pulp stem cellsFerroptosisROS-ScavengingShear-thinning hydrogelSynaptic regulation

Identifiers

PMID36263097
PMCPMC9556860

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.