Evidence map›Paper›PMID 36263124›Full record

ArticleFrontiers in pharmacology2022

Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder.

Caroline W Grant, Angelina R Wilton, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Taryn Mayes, Thomas Carmody, Liewei Wang, Konstantinos Lazaridis, Richard Weinshilboum and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Caroline W GrantDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
Angelina R WiltonDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
Rima Kaddurah-DaoukDepartment of Psychiatry and Behavioral Sciences, Department of Medicine, Duke Institute for Brain Sciences, Duke University, Durham, NC, United States.
Michelle SkimeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
Joanna BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.
Taryn MayesPeter O'Donnell Jr. Brain Institute and the Department of Psychiatry at the University of Texas Southwestern Medical Center, Dallas, TX, United States.
Thomas CarmodyDepartment Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Liewei WangDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
Konstantinos LazaridisDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Richard WeinshilboumDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
William V BoboDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States.
Madhukar H TrivediPeter O'Donnell Jr. Brain Institute and the Department of Psychiatry at the University of Texas Southwestern Medical Center, Dallas, TX, United States.
Paul E CroarkinDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
Arjun P AthreyaDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
WinnMed · USMayo Clinic · USThe University of Texas Southwestern Medical Center · USMayo Clinic in Florida · USDuke University · USMayo Clinic in Arizona · US

Funding

Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0M
INHERITED VARIATIONS IN DRUG-METABOLIZING ENZYMESR01GM028157 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 1985 to 2019
$6.9M
Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type DementiasRF1AG051550 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KLING, MITCHEL ALLAN · 2015 to 2016
$6.3M
Metabolic Networks and Pathways in Alzheimer's DiseaseR01AG046171 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F · 2014 to 2017
$4.4M
Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed PharmacogenomicsR01AA027486 · NIAAA · MAYO CLINIC ROCHESTER · PI Ming-Fen Ho, Richard M. Weinshilboum · 2018 to 2026
$4.0M
Metabolomic Signatures Predictive of Outcomes to Treatments for Major DepressionR01MH108348 · NIMH · DUKE UNIVERSITY · PI DUNLOP, BOADIE W, KADDURAH-DAOUK, RIMA F · 2016 to 2019
$2.7M
Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent DepressionR01MH113700 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2017 to 2021
$2.5M
A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents with Suicidal Ideation Associated with Major Depressive DisorderR01MH124655 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2020 to 2023
$2.4M
NIAAA NIH HHS R01 AA027486NIA NIH HHS R01 AG046171NIA NIH HHS RF1 AG051550NIA NIH HHS U01 AG061359NIA NIH HHS U19 AG063744NIGMS NIH HHS R01 GM028157NIMH NIH HHS R01 MH108348NIMH NIH HHS R01 MH113700NIMH NIH HHS R01 MH124655
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

circadian rhythmdepressiongenomicsmachine learningmulti-omicssuicide

Identifiers

PMID36263124
PMCPMC9573988
OpenAlexW4300962091

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.