Evidence map›Paper›PMID 36264270›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2022

Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca

Kerry McLaughlin, Samuel Acreman, Sameena Nawaz, Joseph Cutteridge, Anne Clark, Jakob G Knudsen, Geoffrey Denwood, Aliya F Spigelman, Jocelyn E Manning Fox, Sumeet Pal Singh and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis CaDiabetic medicine : a journal of the British Diabetic Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 5 countries.

Kerry McLaughlinOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Samuel AcremanOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Sameena NawazOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Joseph CutteridgeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Anne ClarkOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Jakob G KnudsenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Geoffrey DenwoodOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Aliya F SpigelmanAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Jocelyn E Manning FoxAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Sumeet Pal SinghIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Patrick E MacDonaldAlberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Benoit HastoyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Quan ZhangOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.ORCID 0000-0002-3626-4855
Churchill Hospital · GBUniversity of Alberta · CAUniversité Libre de Bruxelles · BEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTetraspanin-7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate β-cell L-type Ca

methodsHistological analyses were conducted using immunostaining. Whole-body metabolism was tested using glucose tolerance test. Islet hormone secretion was quantified using static batch incubation or dynamic perifusion. β-cell transmembrane currents, electrical activity and exocytosis were measured using whole-cell patch-clamping and capacitance measurements. Gene expression was studied using mRNA-sequencing and quantitative PCR.

resultsTspan7 is expressed in insulin-containing granules of pancreatic β-cells and glucagon-producing α-cells. Tspan7 knockout mice (Tspan7

conclusionTspan7 is involved in the regulation of Ca

Indexed as

Insulin-Secreting CellsIslets of LangerhansAnimalsExocytosisGlucoseHumansInsulinMiceNerve Tissue ProteinsTetraspaninsGlucoseInsulinNerve Tissue ProteinsTetraspaninsTSPAN7 protein, humanexocytosisinsulinsynaptotagmintetraspanin-7β-cell

Identifiers

PMID36264270
PMCPMC9828109
OpenAlexW4306912051

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.