Evidence mapPaperPMID 36266413Full record

ArticleScientific reports2022

Breast milk mesenchymal stem cells abate cisplatin-induced cardiotoxicity in adult male albino rats via modulating the AMPK pathway.

Mahitab M Nageeb, Sara F Saadawy, Seba Hassan Attia

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Mediators of inflammation · 2025
    Article
  5. Breast Milk Stem Cells in the Treatment of Neonatal Diseases.Current stem cell research & therapy · 2025
    Review
  6. Article
  7. Article
  8. Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal transduction and targeted therapy · 2023
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mahitab M NageebClinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sara F SaadawyMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Seba Hassan AttiaClinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. SHAttia@medicine.zu.edu.eg.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial injury influenced by cisplatin (Cis) is a compelling reason to hunt out a treatment modality to overcome such a threat in cisplatin-treated patients. Breast Milk mesenchymal stem cells (Br-MSCs) are a non-invasive, highly reproducible source of stem cells. Herein, we investigate Br-MSCs' role in cardiotoxicity induced by cisplatin. Rats were divided into; control, Cis-treated (received 12 mg/kg single intraperitoneal injection), BrMSCs-treated (received single intraperitoneal injection of 0.5 ml sterilized phosphate-buffered saline containing 2 × 10

Indexed as

CardiotoxicityCisplatinMesenchymal Stem CellsMetforminAMP-Activated Protein KinasesAnimalsAnti-Inflammatory AgentsAntioxidantsApoptosisbcl-2-Associated X ProteinCreatine Kinase, MB FormHumansMaleMalondialdehydeMilk, HumanOxidative StressAMP-Activated Protein KinasesAnti-Inflammatory AgentsAntioxidantsbcl-2-Associated X ProteinCisplatinCreatine Kinase, MB FormMalondialdehydeMetforminSuperoxide DismutaseTroponin TTumor Necrosis Factor-alpha

Identifiers

PMID36266413
PMCPMC9585145
OpenAlexW4306879155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.