ArticleiScience2022
Cortical contributions to locomotor primitives in toddlers and adults.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Functional symmetrization of neuromotor modules during locomotor development in human infants.Communications biology · 2025Article
- Developmental changes in upper limb muscle synergies during throwing: A comparison between preschoolers and schoolers.iScience · 2025Article
- Exploring the cortical involvement in sensorimotor integration during early stages of independent walking.Experimental brain research · 2025Article
- Quantifying the diverse contributions of hierarchical muscle interactions to motor function.iScience · 2025Article
- Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task.Frontiers in neural circuits · 2025Article
- Lateralized modulation of cortical beta power during human gait is related to arm swing.iScience · 2024Article
- Dynamics of brain-muscle networks reveal effects of age and somatosensory function on gait.iScience · 2024Article
- Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies.Journal of neurophysiology · 2024Article
- Network of muscle fibers activation facilitates inter-muscular coordination, adapts to fatigue and reflects muscle function.Communications biology · 2023Article
- Development of running is not related to time since onset of independent walking, a longitudinal case study.Frontiers in human neuroscience · 2023Article
- Neurodevelopmental trajectories from birth to childhood and their impairments: insights from passive, spontaneous, and locomotor-like movements.Frontiers in neurologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural locomotor system strongly relies on spinal circuitries. Yet, the control of bipedal gait is accompanied by activity in motor cortex. In human gait control, the functional interaction between these cortical contributions and their spinal counterparts are largely elusive. We focused on four spinal activation patterns during walking and explored their cortical signatures in toddlers and adults. In both groups, cortico-spinal coherence analysis revealed activity in primary motor cortex to be closely related to two of the four spinal patterns. Their corresponding muscle synergies are known to develop around the onset of independent walking. By hypothesis, the cortex hence contributes to the emergence of these synergies. In contrast, the other two spinal patterns investigated here resembled those present during newborn stepping. As expected, they did not show any cortical involvement. Together, our findings suggest a crucial role of motor cortex for independent walking in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.