Evidence map›Paper›PMID 36268658›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2022

Is decision-making impairment an endophenotype of anorexia nervosa?

Laura Di Lodovico, Audrey Versini, Mathieu Lachatre, Jacopo Marcheselli, Nicolas Ramoz, Philip Gorwood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura Di LodovicoClinique des Maladies Mentales et de l'Encéphale, Hopital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences, Paris, France.ORCID 0000-0002-0328-338X
Audrey VersiniUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.
Mathieu LachatreARIA (Now SUEZ), Boulogne-Billancourt, France.ORCID 0000-0002-6984-5170
Jacopo MarcheselliInternational School for Advanced Studies (SISSA), Trieste, Italy.ORCID 0000-0002-2731-4582
Nicolas RamozUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.ORCID 0000-0002-8070-9938
Philip GorwoodClinique des Maladies Mentales et de l'Encéphale, Hopital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences, Paris, France.ORCID 0000-0003-1845-3676
Inserm · FRARIA Technologies · FRScuola Internazionale Superiore di Studi Avanzati · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker (i.e., being associated with AN at any stage of the disease) or a state parameter of the disease (i.e., being present only in acutely ill patients), and if it has endophenotypic characteristics. The aim of this study was to determine the endophenotypic, and state- or trait-associated nature of decision-making impairment in AN.

methodsNinety-one patients with acute AN (A-AN), 90 unaffected relatives (UR), 23 patients remitted from AN (R-AN), and 204 healthy controls (HC) carried out the Iowa gambling task (IGT). Prospective valence learning (PVL) model was employed to distinguish the cognitive dimensions underlying the decision-making process, that is, learning, consistency, feedback sensitivity, and loss aversion. IGT performance and decision-making dimensions were compared among groups to assess whether they had endophenotypic (i.e., being present in A-AN, UR, and R-AN, but not in HC) and/or trait-associated features (i.e., present in A-AN and R-AN but not in HC).

resultsPatients with A-AN had lower performance at the IGT (

conclusionsAlteration of decision-making ability did not show endophenotypic features. Impaired decision-making seems a state-associated characteristic of AN, resulting from the interplay between trait-associated low feedback sensitivity and state-associated features of the disease.

Indexed as

Anorexia NervosaGamblingDecision MakingEndophenotypesHumansNeuropsychological TestsProspective StudiesAnorexia nervosaBayesiandecision-makingendophenotypeIowa gambling task

Identifiers

PMID36268658
PMCPMC9677444
OpenAlexW4306976406

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.