Evidence map›Paper›PMID 36278745›Full record

ArticleJournal of functional morphology and kinesiology2022

A Randomised Controlled Trial of

Ambrish Singh, Dawn Aitken, Steffany Moonaz, Andrew J Palmer, Leigh Blizzard, Changhai Ding, Stan Drummen, Graeme Jones, Kim Bennell, Benny Antony

Abstract read
In one paragraph

Article in Journal of functional morphology and kinesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. A Randomised Controlled Trial ofJournal of functional morphology and kinesiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ambrish SinghMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0002-4618-7507
Dawn AitkenMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Steffany MoonazDepartment of Health Services Research, Southern California University of Health Sciences, Whittier, CA 90604, USA.
Andrew J PalmerMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Leigh BlizzardMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Changhai DingMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Stan DrummenMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Graeme JonesMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Kim BennellDepartment of Physiotherapy, School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne VIC 3010, Australia.
Benny AntonyMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0001-8704-6084

Funding

Rebecca L. Cooper Medical Research Foundation This trial is funded by the Rebecca L Cooper Medical Research Foundation
6 · The paper itself

Abstract

Osteoarthritis (OA) is a common joint disorder for which there is no cure. Current treatments are suboptimal. Exercise is a core treatment for knee OA, with muscle strengthening exercise commonly recommended. Yoga is a mind-body exercise intervention that can improve flexibility, muscle strength, balance, and fitness and potentially reduce symptoms of OA. However, there is a scarcity of robust, high-quality conclusive evidence on the efficacy of yoga in knee OA. We are currently conducting the first randomised comparative effectiveness and cost-effectiveness trial of a yoga program compared with a strengthening exercise program in patients with symptomatic knee OA. This study protocol describes the design and conduct of this trial. The YOGA study is a phase III, single-centre, parallel, superiority, randomised, active-controlled trial which will be conducted in Hobart, Australia. One hundred and twenty-six participants (63 in each arm) aged over 40 years with symptomatic knee OA will be recruited from the community and randomly allocated to receive either a 24-week yoga program (3×/week) or a strengthening exercise program (3×/week). The primary outcome will be change in knee pain over 12 weeks, assessed using a 100 mm visual analogue scale (VAS). The secondary outcomes include change in knee pain, patient global assessment, physical function, quality of life, gait speed, biomarkers, and others over 12 and 24 weeks. We will also assess whether the presence of neuropathic pain moderates the effects of yoga compared to strengthening exercise. Additional data, such as cost and resource utilization, will be collected for the cost-effectiveness analysis. The primary analysis will be conducted using an intention-to-treat approach. Adverse events will be monitored throughout the study. Once completed, this trial will contribute to the knowledge of whether yoga can be used as a simple, effective, low-cost option for the management of knee OA, thus saving economic costs in the healthcare system.

Indexed as

comparative effectiveness researchknee osteoarthritisrandomised controlled trialyoga: strengthening exercise

Identifiers

PMID36278745
PMCPMC9624302

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.