Evidence map›Paper›PMID 36284289›Full record

Trial reportBMC anesthesiology2022

Effects of different depth of anesthesia on perioperative inflammatory reaction and hospital outcomes in elderly patients undergoing laparoscopic radical gastrectomy.

An-Qing Lv, Li-Cai Huang, Wei-Long Lao, Qi-Liang Song, Qi-Fu Zhou, Zong-Ming Jiang, Zhong-Hua Chen

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

An-Qing LvDepartment of Anesthesia, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Yuecheng District, 312000, Shaoxing, China.
Li-Cai HuangDepartment of Anesthesia, Shaoxing University School of Medicine, 312000, Shaoxing, China.
Wei-Long LaoDepartment of Anesthesia, Shaoxing University School of Medicine, 312000, Shaoxing, China.
Qi-Liang SongDepartment of Anesthesia, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Yuecheng District, 312000, Shaoxing, China.
Qi-Fu ZhouDepartment of Anesthesia, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Yuecheng District, 312000, Shaoxing, China.
Zong-Ming JiangDepartment of Anesthesia, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Yuecheng District, 312000, Shaoxing, China.
Zhong-Hua ChenDepartment of Anesthesia, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Yuecheng District, 312000, Shaoxing, China. view55@21cn.com.
Shaoxing People's Hospital · CNShaoxing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the effect of different depth of anesthesia on inflammatory factors and hospital outcomes in elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer, in order to select an appropriate depth of anesthesia to improve the prognosis of patients undergoing surgery and improve the quality of life of patients.

methodsA total of 80 elderly patients aged 65 and above who underwent laparoscopic radical gastrectomy in our hospital were by convenience sampling and randomly divided into two groups : 55 groups ( group H ) and 45 groups ( group L ), 40 cases in each group. The depth of anesthesia was maintained using a closed-loop target-controlled infusion system: the EEG bispectral index was set to 55 in the H group and 45 in the L group. Venous blood samples were collected 2 h (T2), 24 h (T3) and 72 h (T4) after the start of surgery. The intraoperative dosage of propofol and remifentanil, operation duration, postoperative PACU stay time, intraoperative consciousness occurrence, postoperative hospital stay and postoperative pulmonary inflammatory events were recorded.

resultsThe patient characteristic of the two groups had no statistical difference and were comparable (P > 0.05). The intraoperative dosage of propofol in group H was lower than that in group L (P < 0.05). Compared with the L group, the plasma IL-6 and IL-10 concentrations in the H group were significantly increased at T2 (P < 0.05), and the plasma IL-10 concentration was significantly increased at T4 (P < 0.05). The plasma concentrations of IL-6 and IL-10 were higher in both groups at T2, T3 and T4 than at T1, while at T4, the concentration of TNF-α in group H was higher than at T1 (P < 0.05).

conclusionWhen the BIS value of the depth of anesthesia is 45, the perioperative release of inflammatory factors in elderly patients with laparoscopic radical gastrectomy for gastric cancer is less than BIS 55, and does not affect the prognosis.

Indexed as

LaparoscopyPropofolStomach NeoplasmsAgedAnesthesia, GeneralGastrectomyHospitalsHumansInterleukin-10Interleukin-6Quality of LifeRemifentanilTumor Necrosis Factor-alphaInterleukin-10Interleukin-6PropofolRemifentanilTumor Necrosis Factor-alphaBispectral indexClosed-loop target controlDepth of anesthesiaElderly patientsInflammatory factors

Identifiers

PMID36284289
PMCPMC9594928
OpenAlexW4307379655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.