Evidence map›Paper›PMID 36285521›Full record

ArticleEMBO reports2022

Myotubularin functions through actomyosin to interact with the Hippo pathway.

Liang Hu, Wyatt Brichalli, Naren Li, Shifan Chen, Yaqing Cheng, Qinfang Liu, Yulan Xiong, Jianzhong Yu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Liang HuDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.ORCID 0000-0002-9386-6406
Wyatt BrichalliDepartment of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, USA.
Naren LiDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
Shifan ChenDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0001-8522-7527
Yaqing ChengDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
Qinfang LiuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0003-2930-3892
Yulan XiongDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0003-1649-7552
Jianzhong YuDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.ORCID 0000-0002-4883-646X
University of Connecticut · USKansas State University · US

Funding

Molecular Regulation of LRRK2 in Parkinson's DiseaseR01NS112506 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XIONG, YULAN · 2020 to 2024
$1.8M
Upstream regulation of the Hippo signaling pathwayR01GM136904 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI YU, JIANZHONG · 2020 to 2024
$1.7M
The role of aging in LRRK2-associated Parkinsons diseaseK01AG046366 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XIONG, YULAN · 2014 to 2018
$647k
NIA NIH HHS K01 AG046366NIGMS NIH HHS R01 GM136904NINDS NIH HHS R01 NS112506
6 · The paper itself

Abstract

The Hippo pathway is an evolutionarily conserved developmental pathway that controls organ size by integrating diverse regulatory inputs, including actomyosin-mediated cytoskeletal tension. Despite established connections between the actomyosin cytoskeleton and the Hippo pathway, the upstream regulation of actomyosin in the Hippo pathway is less defined. Here, we identify the phosphoinositide-3-phosphatase Myotubularin (Mtm) as a novel upstream regulator of actomyosin that functions synergistically with the Hippo pathway during growth control. Mechanistically, Mtm regulates membrane phospholipid PI(3)P dynamics, which, in turn, modulates actomyosin activity through Rab11-mediated vesicular trafficking. We reveal PI(3)P dynamics as a novel mode of upstream regulation of actomyosin and establish Rab11-mediated vesicular trafficking as a functional link between membrane lipid dynamics and actomyosin activation in the context of growth control. Our study also shows that MTMR2, the human counterpart of Drosophila Mtm, has conserved functions in regulating actomyosin activity and tissue growth, providing new insights into the molecular basis of MTMR2-related peripheral nerve myelination and human disorders.

Indexed as

ActomyosinHippo Signaling PathwayHumansPhosphatidylinositol PhosphatesActomyosinphosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesActomyosinHippo pathwayMyotubularinPI(3)PRab11

Identifiers

PMID36285521
PMCPMC9724681
OpenAlexW4307344856

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.