Evidence map›Paper›PMID 36286429›Full record

ArticleMarine drugs2022

The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway.

Isabel Vidal, Laura Castilla, Ana Dácil Marrero, Inés Bravo-Ruiz, Manuel Bernal, Inmaculada Manrique, Ana R Quesada, Miguel Ángel Medina, Beatriz Martínez-Poveda

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Isabel VidalDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0002-2396-3323
Laura CastillaDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.
Ana Dácil MarreroDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.
Inés Bravo-RuizDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0002-6932-9619
Manuel BernalDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0003-0412-3035
Inmaculada ManriqueDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.
Ana R QuesadaDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0002-6419-8867
Miguel Ángel MedinaDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0001-7275-6462
Beatriz Martínez-PovedaDepartamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, 29071 Málaga, Spain.ORCID 0000-0003-3927-3877
Instituto de Salud Carlos III · ESInstituto de Investigación Biomédica de Málaga · ESUniversidad de Málaga · ES

Funding

Ministerio de Ciencia e Innovación, Gobierno de España PID2019-105010RB-I00Regional Government of Andalusia Group BIO 267Regional Government of Andalusia PY20_00257Regional Government of Andalusia UMA18-FEDERJA-220
6 · The paper itself

Abstract

(+)-Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge

Indexed as

NF-kappa BPoriferaAcetonitrilesAnimalsAnti-Inflammatory AgentsCyclohexenesHumansHuman Umbilical Vein Endothelial CellsI-kappa B KinaseLipopolysaccharidesProto-Oncogene Proteins c-aktSignal TransductionTumor Necrosis Factor-alphaAcetonitrilesaeroplysinin IAnti-Inflammatory AgentsCyclohexenesI-kappa B KinaseLipopolysaccharidesNF-kappa BProto-Oncogene Proteins c-aktTumor Necrosis Factor-alphaaeroplysinin-1atherosclerosisendothelial cellsinflammationmarine-sponge-derived metabolitesNF-κB pathwayPI3K/Akt pathway

Identifiers

PMID36286429
PMCPMC9605425
OpenAlexW4297541666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.