Evidence map›Paper›PMID 36289639›Full record

ArticleBiomedicines2022

Postnatal Conditional Deletion of

Sicheng Song, Jordi Creus Muncunill, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, B Wade Hamilton, Akos A Gerencser, Houda Benlhabib, Maria-Daniela Cirnaru, Mark Leid, Sean D Mooney and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Sicheng SongDepartment of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Jordi Creus MuncunillDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Carlos Galicia AguirreBuck Institute for Research on Aging, Novato, CA 94945, USA.
Kizito-Tshitoko TshilengeBuck Institute for Research on Aging, Novato, CA 94945, USA.
B Wade HamiltonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-9510-5611
Akos A GerencserBuck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0002-8052-3711
Houda BenlhabibDepartment of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-7776-1508
Maria-Daniela CirnaruDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mark LeidDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0002-2906-6703
Sean D MooneyDepartment of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Lisa M EllerbyBuck Institute for Research on Aging, Novato, CA 94945, USA.ORCID 0000-0002-9050-7977
Michelle E EhrlichDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of Washington · USBuck Institute for Research on Aging · USUniversity of Southern California · USWashington State University Spokane · US

Funding

Identifying Factors Regulating Medium Spiny Neuron Differentiation or Maintenance as Therapeutic Targets for Huntington's Disease using Induced Pluripotent Stem CellsR01NS100529 · NINDS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Lisa M Ellerby · 2016 to 2026
$5.6M
NIH HHS R01-NS100529NINDS NIH HHS R01 NS100529
6 · The paper itself

Abstract

The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington's disease (HD), Parkinson's disease, X-linked dystonia-parkinsonism (XDP), addiction, autism, and schizophrenia. Striatal medium spiny neurons (MSNs) make up 90% of the neurons in the striatum and are critical to motor control. The transcription factor,

Indexed as

BCL11BBcl11b conditional knockoutCTIP2Huntington’s diseaseinduced pluripotent stem cellsstriatal medium spiny neuronstranscriptomics

Identifiers

PMID36289639
PMCPMC9598565
OpenAlexW4297147011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.