Evidence map›Paper›PMID 36291201›Full record

ArticleBrain sciences2022

Identification and Characterization of Elevated Expression of Transferrin and Its Receptor TfR1 in Mouse Models of Depression.

Xin Chang, Mengxin Ma, Liping Chen, Zhihong Song, Zhe Zhao, Wei Shen, Huihui Jiang, Yan Wu, Ming Fan, Haitao Wu

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xin ChangSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Mengxin MaDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Liping ChenDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Zhihong SongDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID 0000-0001-6526-5147
Zhe ZhaoDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Wei ShenDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Huihui JiangDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Yan WuDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Ming FanDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Haitao WuSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.ORCID 0000-0001-8437-3194
Beijing Institute of Education · CN

Funding

the Beijing Municipal Science and Technology Commission Z181100001518001 and Z161100000216154the National Key Research and Development Program of China 2021ZD0202500 and 2021YFA1101801the National Natural Science Foundation of China 32171148 and 31770929
6 · The paper itself

Abstract

Depression has become one of the severe mental disorders threatening global human health. In this study, we first used the proteomics approach to obtain the differentially expressed proteins in the liver between naive control and chronic social defeat stress (CSDS) induced depressed mice. We have identified the upregulation of iron binding protein transferrin (TF) in the liver, the peripheral blood, and the brain in CSDS-exposed mice. Furthermore, bioinformatics analysis of the Gene Expression Omnibus (GEO) database from various mouse models of depression revealed the significantly upregulated transcripts of

Indexed as

bioinformaticsblood-brain barrier (BBB)chronic social defeat stress (CSDS)depressionmental disordersproteomicstransferrin receptor 1 (TfR1)transferrin (TF)

Identifiers

PMID36291201
PMCPMC9599150
OpenAlexW4296466549

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.