ArticleBrain sciences2022
Mediating Effect of Loneliness in the Relationship between Depressive Symptoms and Cognitive Frailty in Community-Dwelling Older Adults.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Prevalence and influencing factors of cognitive frailty in patients with chronic heart failure: a meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Persistent socio-demographic inequalities in depression among older adults in China during and after COVID-19: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Pooled it
- Depression, anxiety, anger, and loneliness in older adults: comparing residential contexts and examining the role of loneliness.BMC geriatrics · 2026Article
- The predictive role of feeling lonely in nursing home placement in older adults hospitalized in an emergency setting.Aging clinical and experimental research · 2026Observational
- The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study.BMC public health · 2025Article
- The mediating role of sarcopenia in the link between loneliness and frailty among nursing home residents: a cross-sectional study.BMC geriatrics · 2025Article
- Repetitive negative thinking is associated with cognitive function decline in older adults: a cross-sectional study.BMC psychiatry · 2025Article
- Moderating effect of instrumental activities of daily living on the relationship between loneliness and depression in people with cognitive frailty.BMC geriatrics · 2025Article
- Prevalence and modifiable risk factors of cognitive frailty in patients with chronic heart failure in China: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms.Clinical interventions in aging · 2024Article
- Institutional Residence Protects Against Cognitive Frailty: A Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThis study aims to explore the mediating role of loneliness between depressive symptoms and cognitive frailty among older adults in the community.
methodsA total of 527 community-dwelling older adults aged ≥ 60 years were included in this cross-sectional study. A five-item geriatric depression scale was used to assess depression symptoms. Then, an eight-item University of California at Los Angeles Loneliness Scale was used to assess loneliness. Moreover, the FRAIL scale and Mini-Mental State Examination were used to assess cognitive frailty. Furthermore, regression and bootstrap analyses were used to explore the mediating role of loneliness in depression symptoms and cognitive frailty.
resultsLoneliness mediates the association between depression symptoms and cognitive frailty (95% CI = 0.164~0.615), and after adjusting for loneliness, the direct effect is no longer significant (95% CI = -0.113~1.318,
conclusionsResults show that the effect of cognitive frailty is not depression symptoms but loneliness. All levels of society (the government, medical institutions, and communities) need to pay more attention to the mental health of the older adults, screen for loneliness, and take timely intervention and treatment measures. They should also build an age-friendly society and promote active aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.