Evidence map›Paper›PMID 36291579›Full record

ArticleBiomolecules2022

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity.

Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J Degroat, Yuxiang Sun, Troy A Roepke

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kristie CondeGraduate Program in Neuroscience, Rutgers University Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ 08901, USA.ORCID 0000-0002-9525-4606
Danielle KulykDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Allison VanschaikDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Sierra DaiseyDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Catherine RojasJoint Graduate Program in Toxicology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Kimberly WiersielisDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Ali YasrebiDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Thomas J DegroatDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Yuxiang SunDepartment of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX 77843, USA.
Troy A RoepkeGraduate Program in Neuroscience, Rutgers University Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ 08901, USA.ORCID 0000-0001-5426-2266
Rutgers, The State University of New Jersey · USTexas A&M University · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Sex differences in CRH signaling in the ovBNST underlie effects of chronic stressorsR01MH123544 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI ROEPKE, TROY ADAM, SAMUELS, BENJAMIN A · 2020 to 2024
$2.4M
CRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2M
Disruption of arcuate gene expression and neuronal activity by OPFRR21ES027119 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI ROEPKE, TROY ADAM · 2017 to 2018
$540k
NICHD NIH HHS R24 HD102061NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022NIEHS NIH HHS R21 ES027119NIEHS NIH HHS T32 ES007148NIMH NIH HHS R01 MH123544NIMH NIH HHS R01MH123544
6 · The paper itself

Abstract

The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC). We have shown 17β-estradiol (E2) increases

Indexed as

Receptors, GhrelinAnimalsArcuate Nucleus of HypothalamusDiet, High-FatDynorphinsEstradiolFemaleGhrelinGlucoseKisspeptinsMiceNeurokinin BNeuronsObesityDynorphinsEstradiolGhrelinGlucoseKisspeptinsNeurokinin BReceptors, Ghrelin17β-estradiolenergy homeostasisghrelinGHSRKisspeptinreproduction

Identifiers

PMID36291579
PMCPMC9599822
OpenAlexW4297150521

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.