Evidence map›Paper›PMID 36292585›Full record

ArticleGenes2022

Differentially Methylated DNA Regions and Left Ventricular Hypertrophy in African Americans: A HyperGEN Study.

Alana C Jones, Amit Patki, Steven A Claas, Hemant K Tiwari, Ninad S Chaudhary, Devin M Absher, Leslie A Lange, Ethan M Lange, Wei Zhao, Scott M Ratliff and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Alana C JonesDepartment of Epidemiology, School of Public Health, University of Alabama-Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0003-3827-2426
Amit PatkiDepartment of Biostatistics, School of Public Health, University of Alabama-Birmingham, Birmingham, AL 35233, USA.
Steven A ClaasDepartment of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0001-9789-8395
Hemant K TiwariDepartment of Biostatistics, School of Public Health, University of Alabama-Birmingham, Birmingham, AL 35233, USA.
Ninad S ChaudharyDepartment of Epidemiology, School of Public Health, University of Alabama-Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0003-1350-1093
Devin M AbsherHudson Alpha Institute of Biotechnology, Huntsville, AL 35806, USA.
Leslie A LangeDepartment of Epidemiology, School of Public Health, University of Colorado, Aurora, CO 80045, USA.
Ethan M LangeDepartment of Biomedical Informatics, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4032-5745
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3575-5468
Marguerite R IrvinDepartment of Epidemiology, School of Public Health, University of Alabama-Birmingham, Birmingham, AL 35233, USA.
Donna K ArnettDepartment of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY 40506, USA.
University of Alabama at Birmingham · USUniversity of Michigan · USColorado School of Public Health · USUniversity of Kentucky · USHudsonAlpha Institute for Biotechnology · US

Funding

HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1M
Epigenetics of Arteriosclerosis in African American Hypertensive SibshipsR01HL133221 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, JENNIFER ANN · 2016 to 2019
$2.2M
Genetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1M
Epigenetic Biomarkers of Common Chronic DiseasesRC1HL100185 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2009 to 2010
$999k
Genetic and Epigenetic Risk Scores for Chronic Kidney Disease in African AmericansF31DK128990 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JONES, ALANA CHRISTINE · 2021 to 2023
$128k
GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPSU10HL054457 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SING, CHARLES F · 1995 to 1999
–
NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL133221NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U10 HL054457NIDDK NIH HHS F31 DK128990NIDDK NIH HHS F31DK128990NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

Left ventricular (LV) hypertrophy (LVH) is an independent risk factor for cardiovascular disease, and African Americans experience a disparate high risk of LVH. Genetic studies have identified potential candidate genes and variants related to the condition. Epigenetic modifications may continue to help unravel disease mechanisms. We used methylation and echocardiography data from 636 African Americans selected from the Hypertension Genetic Epidemiology Network (HyperGEN) to identify differentially methylated regions (DMRs) associated with LVH. DNA extracted from whole blood was assayed on Illumina Methyl450 arrays. We fit linear mixed models to examine associations between co-methylated regions and LV traits, and we then conducted single CpG analyses within significant DMRs. We identified associations between DMRs and ejection fraction (

Indexed as

HypertensionHypertrophy, Left VentricularBlack or African AmericanDNAHumansMolecular EpidemiologyDNADMRDNA methylationepigeneticsEWASleft ventricular hypertrophy

Identifiers

PMID36292585
PMCPMC9601679
OpenAlexW4296848486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.