ReviewInternational journal of molecular sciences2022
Molecular Mechanisms of Takotsubo Syndrome.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Comparison of troponin and natriuretic peptides in Takotsubo syndrome and acute coronary syndrome: a meta-analysis.Open heart · 2024Pooled it
- Stress-Induced Changes in Contractile Activity of Rat Aorta and Pulmonary Artery.Bulletin of experimental biology and medicine · 2026Article
- Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management.Journal of clinical medicine · 2025Review
- Comparative Meta-Analysis of Left Ventricular Mechanics in Takotsubo Syndrome and Anterior STEMI Due to Left Anterior Descending Artery Occlusion.Journal of clinical medicine · 2025Review
- Pregnancy-Associated Takotsubo Syndrome: A Narrative Review of the Literature.Journal of clinical medicine · 2025Review
- Takotsubo Syndrome Development Immediately Following Hemodialysis Initiation.Internal medicine (Tokyo, Japan) · 2025Article
- Paroxysmal Sympathetic Hyperactivity, Volume Status, and Neurological Prognosis in Acute Brain Injury: A Prospective Cohort Analysis.International journal of general medicine · 2025Article
- Phaeochromocytoma mimicking acute ST-elevation myocardial infarction.BMJ case reports · 2024Article
- Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers.Biomedicines · 2024Review
- Is Takotsubo syndrome induced by patent ductus arteriosus occlusion?BMC cardiovascular disorders · 2024Article
- In-hospital triggers of takotsubo syndrome: a case report on witnessing sudden death in a hospital roommate.European heart journal. Case reports · 2023Article
- From Cardiovascular Prevention and Differential Diagnosis to the Treatment of Myocardial Damage-Experimental and Human Perspectives.International journal of molecular sciences · 2023Article
- Case report: Takotsubo syndrome following percutaneous coronary intervention.Journal of cardiothoracic surgery · 2023Article
- New Concepts on the Pathophysiology of Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2023Review
- Broken Heart Syndrome: Evolving Molecular Mechanisms and Principles of Management.Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Takotsubo syndrome (TTS) is a severe but reversible acute heart failure syndrome that occurs following high catecholaminergic stress. TTS patients are similar to those with acute coronary syndrome, with chest pain, dyspnoea and ST segment changes on electrocardiogram, but are characterised by apical akinesia of the left ventricle, with basal hyperkinesia in the absence of culprit coronary artery stenosis. The pathophysiology of TTS is not completely understood and there is a paucity of evidence to guide treatment. The mechanisms of TTS are thought to involve catecholaminergic myocardial stunning, microvascular dysfunction, increased inflammation and changes in cardiomyocyte metabolism. Here, we summarise the available literature to focus on the molecular basis for the pathophysiology of TTS to advance the understanding of the condition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.