ReviewInternational journal of molecular sciences2022
Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Epidemiological, clinical, and molecular studies on nail disorders in the human population of Punjab, Pakistan.Molecular biology reports · 2026Article
- The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research.Thoracic research and practice · 2026Article
- Insecticides Promote Inflammation and Gut Barrier Alteration in In-Vitro Human Models.Journal of xenobiotics · 2026Article
- Urinary Glyphosate Exposure and Risk of Obstructive Airway Diseases in Youth and Adults: Population-Based Evidence from U.S. Biomonitoring Data.International journal of environmental research and public health · 2026Article
- Age Versus Immunity: Dietary Influences on Immunosenescence.Journal of clinical medicine · 2025Review
- The Role ofToxics · 2025Review
- The Analysis and Risk Assessment of Organic Pollutants in Food Products.Foods (Basel, Switzerland) · 2025Article
- Development and validation of a nomogram to predict atelectasis in adult lymph node fistula tracheobronchial tuberculosis patients.Frontiers in medicine · 2025Article
- Postbiotics as Potential Detoxification Tools for Mitigation of Pesticides.Probiotics and antimicrobial proteins · 2024Review
- Review
- Pesticide use patterns and their association with cytokine levels in Mexican flower workers.International archives of occupational and environmental health · 2024Article
- Pesticides: Unintended Impact on the Hidden World of Gut Microbiota.Metabolites · 2024Review
- Pesticide-Induced Inflammation at a Glance.Toxics · 2023Review
- Dihydromyricetin Attenuates High-Intensity Exercise-Induced Intestinal Barrier Dysfunction Associated with the Modulation of the Phenotype of Intestinal Intraepithelial Lymphocytes.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The environmental and occupational risk we confront from agricultural chemicals increases as their presence in natural habitats rises to hazardous levels, building a major part of the exposome. This is of particular concern in low- and middle-income countries, such as Brazil, known as a leading producer of agricultural commodities and consumer of pesticides. As long as public policies continue to encourage the indiscriminate use of pesticides and governments continue to support this strategy instead of endorsing sustainable agricultural alternatives, the environmental burden that damages epithelial barriers will continue to grow. Chronic exposure to environmental contaminants in early life can affect crucial barrier tissue, such as skin epithelium, airways, and intestine, causing increased permeability, leaking, dysbiosis, and inflammation, with serious implications for metabolism and homeostasis. This vicious cycle of exposure to environmental factors and the consequent damage to the epithelial barrier has been associated with an increase in immune-mediated chronic inflammatory diseases. Understanding how the harmful effects of pesticides on the epithelial barrier impact cellular interactions mediated by endogenous sensors that coordinate a successful immune system represents a crucial challenge. In line with the epithelial barrier hypothesis, this narrative review reports the available evidence on the effects of pesticides on epithelial barrier integrity, dysbiosis, AhR signaling, and the consequent development of immune-mediated inflammatory diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.