Evidence map›Paper›PMID 36293293›Full record

ArticleInternational journal of molecular sciences2022

Elevated Levels of Toxic Bile Acids in Serum of Cystic Fibrosis Patients with

Harold Tabori, Jochen Schneider, Stefan Lüth, Carlos Zagoya, Anton Barucha, Thomas Lehmann, Eberhard Kauf, Astrid Barth, Jochen G Mainz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Pathophysiology of cystic fibrosis-related liver disease.Current opinion in gastroenterology · 2026
    Review
  4. Review
  5. Article
  6. Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Harold TaboriCystic Fibrosis Center, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, 14770 Brandenburg an der Havel, Germany.
Jochen SchneiderCystic Fibrosis Centre, Jena University Hospital, 07740 Jena, Germany.
Stefan LüthDepartment of Gastroenterology, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
Carlos ZagoyaCystic Fibrosis Center, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, 14770 Brandenburg an der Havel, Germany.
Anton BaruchaCystic Fibrosis Center, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, 14770 Brandenburg an der Havel, Germany.
Thomas LehmannInstitute of Medical Statistics, Jena University Hospital, 07743 Jena, Germany.
Eberhard KaufCystic Fibrosis Centre, Jena University Hospital, 07740 Jena, Germany.
Astrid BarthInstitut für Pharmakologie und Toxikologie, Jena University Hospital, 07743 Jena, Germany.
Jochen G MainzCystic Fibrosis Center, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, 14770 Brandenburg an der Havel, Germany.
Jena University Hospital · DEKlinikum Brandenburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatobiliary involvement is a hallmark in cystic fibrosis (CF), as the causative CF Transmembrane Conductance Regulator (CFTR) defect is expressed in the biliary tree. However, bile acid (BA) compositions in regard to pancreatic insufficiency, which is present at an early stage in about 85% of CF patients, have not been satisfactorily understood. We assess the pattern of serum BAs in people with CF (pwCF) without CFTR modulator therapy in regard to pancreatic insufficiency and the

Indexed as

Cystic FibrosisExocrine Pancreatic InsufficiencyLiver DiseasesBile Acids and SaltsCholic AcidCystic Fibrosis Transmembrane Conductance RegulatorGlycineHumansMutationTaurineBile Acids and SaltsCFTR protein, humanCholic AcidCystic Fibrosis Transmembrane Conductance RegulatorGlycineTaurinebile acidbiliaryCF liver diseasecystic fibrosishepatichigh performance liquid chromatography

Identifiers

PMID36293293
PMCPMC9603931
OpenAlexW4306762021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.