ArticleInternational journal of molecular sciences2022
Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Placental molecular subtypes of severe preeclampsia reveal divergent aging trajectories and fetal growth outcomes.medRxiv : the preprint server for health sciences · 2026Article
- In vivo physiological ramifications of placental SLC2A3-RNA interference throughout gestation in sheep.Journal of animal science · 2026Article
- The regulatory roles and therapeutic strategies of the solute carrier transporters in cancer metabolism.NPJ precision oncology · 2026Review
- Asprosin activates multiple placental pathwaysMolecular medicine reports · 2025Article
- Dynamic changes in peripheral blood CD4+ T cell subsets are associated with litter performance in primiparous gestating sows.Journal of animal science · 2025Article
- Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies.American journal of physiology. Endocrinology and metabolism · 2024Article
- Fetal Hypoglycemia Induced by PlacentalInternational journal of molecular sciences · 2024Article
- Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring.World journal of diabetes · 2024Review
- The Impact of SLC2A8 RNA Interference on Glucose Uptake and the Transcriptome of Human Trophoblast Cells.Cells · 2024Article
- Recent insights into the role of hormones during development and their functional regulation.Frontiers in endocrinology · 2024Review
- Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis.Life (Basel, Switzerland) · 2023Article
- Pathogenesis of Pregnancy-Related Complications.International journal of molecular sciences · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In the ruminant placenta, glucose uptake and transfer are mediated by facilitative glucose transporters SLC2A1 (GLUT1) and SLC2A3 (GLUT3). SLC2A1 is located on the basolateral trophoblast membrane, whereas SLC2A3 is located solely on the maternal-facing, apical trophoblast membrane. While SLC2A3 is less abundant than SLC2A1, SLC2A3 has a five-fold greater affinity and transport capacity. Based on its location, SLC2A3 likely plays a significant role in the uptake of glucose into the trophoblast. Fetal hypoglycemia is a hallmark of fetal growth restriction (FGR), and as such, any deficiency in SLC2A3 could impact trophoblast glucose uptake and transfer to the fetus, thus potentially setting the stage for FGR. By utilizing in vivo placenta-specific lentiviral-mediated RNA interference (RNAi) in sheep, we were able to significantly diminish (
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