Evidence map›Paper›PMID 36294526›Full record

ArticleJournal of clinical medicine2022

DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD-Analysis of 10,865 Individuals.

Caitlyn Tan, Kai En Chan, Cheng Han Ng, Michael Tseng, Nicholas Syn, Ansel Shao Pin Tang, Yip Han Chin, Wen Hui Lim, Darren Jun Hao Tan, Nicholas Chew and 10 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Caitlyn TanYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Kai En ChanYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Cheng Han NgYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.ORCID 0000-0002-8297-1569
Michael TsengDivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Nicholas SynYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Ansel Shao Pin TangYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Yip Han ChinYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Wen Hui LimYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Darren Jun Hao TanYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Nicholas ChewDepartment of Cardiology, National University Heart Centre, National University Hospital, Singapore 119074, Singapore.ORCID 0000-0002-0640-0430
Elden Yen Hng OngYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Teng Kiat KohDivision of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore 119074, Singapore.
Jieling XiaoYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Douglas CheeDivision of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore 119074, Singapore.
Arun ValsanDepartment of Gastroenterology and Hepatology, Amrita Hospital, Kochi 682041, India.
Mohammad Shadab SiddiquiDivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Daniel HuangYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Mazen NoureddinHouston Research Institute, Houston, TX 77079, USA.
Karn WijarnpreechaDivision of Gastroenterology and Hepatology, University of Arizona College of Medicine Phoenix, Phoenix, AZ 85004, USA.ORCID 0000-0002-6232-6343
Mark D MuthiahYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
National University of Singapore · SGNational University Hospital · SGVirginia Commonwealth University · USAmrita Institute of Medical Sciences and Research Centre · INHouston Institute for Clinical Research · USNational University Heart Centre Singapore · SGUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide yet predicting non-obese NAFLD is challenging. Thus, this study investigates the potential of regional fat percentages obtained by dual-energy X-ray absorptiometry (DXA) in accurately assessing NAFLD risk. Using the United States National Health and Nutrition Examination Survey (NHANES) 2011−2018, multivariate logistic regression and marginal analysis were conducted according to quartiles of regional fat percentages, stratified by gender. A total of 23,752 individuals were analysed. Males generally showed a larger increase in marginal probabilities of NAFLD development than females, except in head fat, which had the highest predictive probabilities of non-obese NAFLD in females (13.81%, 95%CI: 10.82−16.79) but the lowest in males (21.89%, 95%CI: 20.12−23.60). Increased percent of trunk fat was the strongest predictor of both non-obese (OR: 46.61, 95%CI: 33.55−64.76, p < 0.001) and obese NAFLD (OR: 2.93, 95%CI: 2.07−4.15, p < 0.001), whereas raised percent gynoid and leg fat were the weakest predictors. Ectopic fat deposits are increased in patients with non-obese NAFLD, with greater increases in truncal fat over gynoid fat. As increased fat deposits in all body regions can increase odds of NAFLD, therapeutic intervention to decrease ectopic fat, particularly truncal fat, may decrease NAFLD risk.

Indexed as

dual-energy X-ray absorptiometrylean NAFLDnon-alcoholic fatty liver diseasenon-obese NAFLDobesity

Identifiers

PMID36294526
PMCPMC9605163
OpenAlexW4307262628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.