Evidence map›Paper›PMID 36295076›Full record

ArticleLife (Basel, Switzerland)2022

Spectral Analysis and Antiulcer Potential of

Rahamat Unissa Syed, Sivakumar S Moni, Amr S Abu Lila, Marwa H Abdallah, Amr S Abouzied, Humera Banu, Khetam Saad Mutni Alreshidi, Badriah Mansour Wadid Alrashidi, Mohd Abdul Hadi, Hemat El-Horany and 2 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Molecular docking analysis ofFood science & nutrition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Rahamat Unissa SyedDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.
Sivakumar S MoniDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-4860-0166
Amr S Abu LilaDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0001-7385-868X
Marwa H AbdallahDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0001-6670-3903
Amr S AbouziedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0002-9202-3909
Humera BanuDepartment of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail 81442, Saudi Arabia.
Khetam Saad Mutni AlreshidiCollege of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.
Badriah Mansour Wadid AlrashidiCollege of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.
Mohd Abdul HadiDepartment of Pharmaceutics, School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo 46551, Ethiopia.
Hemat El-HoranyDepartment of Biochemistry, College of Medicine, University of Hail, Hail 81442, Saudi Arabia.
Siddig Ibrahim AbdelwahabMedical Research Center, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-6145-4466
Manal Mohamed Elhassan TahaSubstance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia.
University of Ha'il · SAJazan University · SAZagazig University · EGTanta University · EGWolaita Sodo University · ET

Funding

Scientific Research Deanship at the University of Hail, Saudi Arabia, RG-21 129University of Hail RG-21 129
6 · The paper itself

Abstract

The objective of this study was to characterize the bioactive ingredients and antiulcer effects of Lactuca sativa leaves. Several bioactive chemicals were found in the cold methanolic extract of Lactuca sativa leaves after gas chromatography-mass spectrometry (GC-MS) research: 9,12-octadecadienoic acid (Z,Z)-, cyclononasiloxane, octadecamethyl-, n-hexadecanoic acid, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl, octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 9-octadecenamide, (Z)-, hexadecanoic acid, stigmasterol, benzothiazole, ethyl iso-allocholate, and octacosane. Distinct fingerprint regions in GCMS indicated the existence of bioactive compounds. The leaf powder of Lactuca sativa (LPL) demonstrated substantial antiulcer properties at 400 mg/kg, which was almost equivalent to the standard drug at 20 mg/kg. The cytokine network was efficiently regulated by reducing the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The levels of caspase-3 and caspase-9 were also considerably lowered at p < 0.05 significant level.

Indexed as

anti-ulcer activitybioactive compoundsspectral analysis

Identifiers

PMID36295076
PMCPMC9604980
OpenAlexW4306838954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.