Evidence map›Paper›PMID 36297459›Full record

ArticlePharmaceutics2022

Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of Praziquantel: A Promising Nanovector against

Waleed M Arafa, Mohammed H Elkomy, Heba M Aboud, Mona Ibrahim Ali, Samah S Abdel Gawad, Shawky M Aboelhadid, Emad A Mahdi, Izzeddin Alsalahat, Heba Abdel-Tawab

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  11. Modafinil-excipient compatibility study using differential scanning calorimetry.Journal of advanced pharmaceutical technology & research
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Waleed M ArafaDepartment of Parasitology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.ORCID 0000-0002-9420-1764
Mohammed H ElkomyDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0003-4083-6024
Heba M AboudDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0001-6226-5192
Mona Ibrahim AliDepartment of Medical Parasitology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
Samah S Abdel GawadDepartment of Medical Parasitology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
Shawky M AboelhadidDepartment of Parasitology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.ORCID 0000-0002-1403-2527
Emad A MahdiDepartment of Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.
Izzeddin AlsalahatUK Dementia Research Institute Cardiff, School of Medicine, Cardiff University, Cardiff CF24 1TP, UK.ORCID 0000-0001-8587-7175
Heba Abdel-TawabDepartment of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.
Beni-Suef University · EGJouf University · SAUK Dementia Research Institute · GB

Funding

Al Jouf University DSR-2021-01-03126
6 · The paper itself

Abstract

Hymenolepiasis represents a parasitic infection of common prevalence in pediatrics with intimidating impacts, particularly amongst immunocompromised patients. The present work aimed to snowball the curative outcomes of the current mainstay of hymenolepiasis chemotherapy, praziquantel (PRZ), through assembly of polymeric mixed micelles (PMMs). Such innovative nano-cargo could consolidate PRZ hydrosolubility, extend its circulation time and eventually upraise its bioavailability, thus accomplishing a nanoparadigm for hymenolepiasis tackling at lower dose levels. For consummating this goal, PRZ-PMMs were tailored

Indexed as

Box-Behnken designHymenolepis nanaoral targetingpharmacokineticspolymeric mixed micellespraziquantel

Identifiers

PMID36297459
PMCPMC9608995
OpenAlexW4297238182

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.