Evidence map›Paper›PMID 36298670›Full record

ArticleViruses2022

DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus.

Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Probiotics as Potential Enhancers of Veterinary Vaccines.Probiotics and antimicrobial proteins · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling LiuCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.
Mingrong YinCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.
Yang LiChina Animal Health and Epidemiology Center, Qingdao 266032, China.
Hong SuChina Animal Health and Epidemiology Center, Qingdao 266032, China.
Lichun FangShandong Academy of Agricultural Sciences, Jinan 250100, China.
Xiaolong SunCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.
Shuang ChangCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.
Peng ZhaoCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.
Yixin WangCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.ORCID 0000-0002-8118-4846

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chicken infectious anemia (CIA) is an immunosuppressive disease caused by chicken infectious anemia virus (CIAV) that poses a great threat to the poultry industry worldwide. At present, vaccination is an important way to prevent and control CIA. Apart from a CIAV-attenuated vaccine used in clinical practice, the research and development of a genetically engineered vaccine has good prospects. However, it is difficult to induce a strong protective effect with a single subunit vaccine or DNA vaccine. Therefore, the goal of this study is to develop and evaluate a DNA prime/protein boost vaccine strategy for defense against CIAV infection and spread. In this study, the recombinant proteins of CIAV VP1 and VP2 were prepared using an

Indexed as

Chicken anemia virusCircoviridae InfectionsPoultry DiseasesVaccines, DNAViral VaccinesAnimalsAntibodies, ViralChickensDNAEscherichia coliInterleukin-2Interleukin-4Recombinant ProteinsVaccinationVaccines, AttenuatedVaccines, SubunitAntibodies, ViralDNAInterleukin-2Interleukin-4Recombinant ProteinsVaccines, AttenuatedVaccines, DNAVaccines, SubunitViral Vaccinesantibody titercellular immunitychicken infectious anemia virusDNA prime/protein boostprotective efficacy

Identifiers

PMID36298670
PMCPMC9612391

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.