Evidence map›Paper›PMID 36299576›Full record

ArticleFrontiers in genetics2022

The interconnected relationships between middle ear bulla size, cavitation defects, and chronic otitis media revealed in a syndromic mouse model.

Juan M Fons, Natalie J Milmoe, Michael R G Dack, Leena Joshi, Hannah Thompson, Abigail S Tucker

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.International journal of pediatric otorhinolaryngology · 2024
    Article
  3. Article
  4. Role of a novel mouse mutant of theFrontiers in neurology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Juan M FonsCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Natalie J MilmoeCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Michael R G DackCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Leena JoshiCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Hannah ThompsonCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Abigail S TuckerCentre for Craniofacial and Regenerative Biology, Fl27 Guy's Hospital, King's College London, London, United Kingdom.
Guy's Hospital · GBKing's College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

High incidence of chronic otitis media is associated with human craniofacial syndromes, suggesting that defects in the formation of the middle ear and associated structures can have a knock-on effect on the susceptibility to middle ear inflammation. Patients with branchio-oto-renal (BOR) syndrome have several defects in the ear leading to both sensorineural and conductive hearing loss, including otitis media. 40% of BOR syndrome cases are due to

Indexed as

basal cell hyperplasiabranchio-oto-renal syndromecavitationcongenital birth defectear development

Identifiers

PMID36299576
PMCPMC9590451
OpenAlexW4304013958

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.