Evidence map›Paper›PMID 36299732›Full record

ReviewFrontiers in microbiology2022

Medicinal plants and natural compounds against acyclovir-resistant HSV infections.

Lin Xu, Xuan-Lei Zhong, Zhi-Chao Xi, Yang Li, Hong-Xi Xu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Dentistry journal · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Antiviral and Cytotoxic Activities ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lin XuSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xuan-Lei ZhongSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhi-Chao XiSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yang LiSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hong-Xi XuShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNShuguang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.

Indexed as

acyclovir-resistantantiviral herbsherpes simplex virusmode of actionnatural products

Identifiers

PMID36299732
PMCPMC9589345
OpenAlexW4304161213

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.