Evidence map›Paper›PMID 36301409›Full record

ArticleObesity surgery2022

Peptide Tyrosine-Tyrosine Triggers GLP-2-Mediated Intestinal Hypertrophy After Roux-en-Y Gastric Bypass.

Gonzalo-Martín Pérez-Arana, Alfredo Díaz-Gómez, Alonso Camacho-Ramírez, Antonio Ribelles-García, David Almorza-Gomar, Manuel Gracia-Romero, José-Arturo Prada-Oliveira

Open access · hybridAbstract read
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In one paragraph

Article in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gonzalo-Martín Pérez-AranaDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain. [email protected].
Alfredo Díaz-GómezSan Carlos Hospital, Andalusian Health System, 11100, Andalusia, Spain.
Alonso Camacho-RamírezInstitute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain.
Antonio Ribelles-GarcíaDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain.
David Almorza-GomarInstitute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11009, Cadiz, Spain.
Manuel Gracia-RomeroDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain.
José-Arturo Prada-OliveiraDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003, Plaza Fragela s/n., Cadiz, Spain. [email protected].ORCID 0000-0001-8401-1441
Universidad de Cádiz · ESAndalusian Health Service · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntestinal remodeling and adaptation of the alimentary limb after Roux-en-Y gastric bypass (RYGB) play an important role in the pathophysiological events that lead to type 2 diabetes mellitus (T2DM) improvement. Intestinal absorptive loop hypertrophy and growth following surgery have been related to GLP-2 secretion by ileal L-cells. The secretion of peptide tyrosine-tyrosine (PYY) enterohormone after a meal has been proposed as a trigger for ileal secretion of GLP-1. Our aim is to determine the role of PYY as a GLP-2 secretion modulator as an adaptation result in the alimentary limb after RYGB.

methodWe used a non-obese euglycemic rodent model. Circulating glucose, insulin, PYY, and GLP-2 were measured in the experimental and control groups. We used four groups: fasting control, Sham-operated, RYGB-operated (RYGB), and RYGB-operated and treated with BIIE0246 (RYGB + BII). BIIE0246 is a NPY2 receptor antagonist in L-cells. Intestinal glucose transporters and GLP-1 and PYY gut expression and hypertrophy were analyzed after 12 weeks of surgery.

resultsRYGB increased PYY3-36 plasma levels in rats with or without BII treatment. A high-insulin response was observed in the RYGB group but not in the control or RYGB + BII groups. BIIE0246 treatment limited plasma GLP-2 levels. In the alimentary intestinal limb, hypertrophy and SGLT1 and GLUT1 expression appeared to be reduced after RYGB compared to controls.

conclusionThe postprandial ileal PYY secretion is enhanced after RYGB. This increase mediates GLP-2 release through its binding to the Y2 receptor on L-cells. This mechanism plays a role in alimentary limb hypertrophy after surgery.

Indexed as

Diabetes Mellitus, Type 2Gastric BypassInsulinsObesity, MorbidAnimalsBlood GlucoseDipeptidesGlucagon-Like Peptide 1Glucagon-Like Peptide 2GlucoseHypertrophyRatsBlood GlucoseDipeptidesGlucagon-Like Peptide 1Glucagon-Like Peptide 2GlucoseInsulinstyrosyltyrosineEnterohormonesGlucose transporterIncretinesIntestinal tubePancreasPeptide tyrosine-tyrosinePYYRoux-en-Y gastric bypassRYGBType 2 diabetes mellitus

Identifiers

PMID36301409
PMCPMC9671997
OpenAlexW4307432268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.