ReviewWorld journal of gastroenterology2022
Oxidative stress bridges the gut microbiota and the occurrence of frailty syndrome.
Review in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
- Deciphering the personalized functional redundancy hierarchy in the gut microbiome.Microbiome · 2025Article
- Gut Microbiota Enterotype as a Predictor of Sarcopenia in the Japanese Elderly Population.Nutrients · 2025Article
- Association of the atherogenic index of plasma with frailty in U.S. adults: a cross-sectional study based on NHANES.Lipids in health and disease · 2025Article
- Comprehensive dietary antioxidant index and chronic kidney disease: mediating role of frailty and its impact on mortality outcomes in adults.Frontiers in nutrition · 2025Article
- Analysis of alterations in the composition of the intestinal microbiota in frail older individuals.PloS one · 2025Article
- Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies.World journal of clinical cases · 2024Article
- Geroprotective effects of GdVOBiogerontology · 2024Article
- Article
- Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications.Psychopharmacology · 2024Review
- Mind, Mood and Microbiota-Gut-Brain Axis in Psychiatric Disorders.International journal of molecular sciences · 2024Review
- Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.Microorganisms · 2024Article
- Intestinal barrier damage contributes to a higher prevalence of frailty in aging people living with HIV: a retrospective case control study in a Chinese cohort.Frontiers in immunology · 2024Article
- The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress.Clinical interventions in aging · 2024Article
- Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms.Gut microbes · 2023Review
- Inflammation and Oxidative Stress in Frailty and Metabolic Syndromes-Two Sides of the Same Coin.Metabolites · 2023Review
- Microbial Composition and Stool Short Chain Fatty Acid Levels in Fibromyalgia.International journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of frailty gradually increases with age. This condition places a heavy burden on modern society, of which the aging population is increasing. Frailty is one of the most complicated clinical syndromes; thus, it is difficult to uncover its underlying mechanisms. Oxidative stress (OS) is involved in frailty in multiple ways. The association between the gut microbiota (GM) and frailty was recently reported. Herein, we propose that OS is involved in the association between the GM and the occurrence of frailty syndrome. An imbalance between oxidation and antioxidants can eventually lead to frailty, and the GM probably participates in this process through the production of reactive oxygen species. On the other hand, OS can disturb the GM. Such dysbiosis consequently induces or exacerbates tissue damage, leading to the occurrence of frailty syndrome. Finally, we discuss the possibility of improving frailty by intervening in the vicious cycle between the imbalance of OS and dysbiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.