Evidence map›Paper›PMID 36306436›Full record

ArticleBiochemistry2022

The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability.

Jacob P Sieg, Lauren N McKinley, Melanie J Huot, Neela H Yennawar, Philip C Bevilacqua

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  10. Structure of pre-miR-31 reveals an active role in Dicer-TRBP complex processing.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jacob P SiegDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Lauren N McKinleyDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Melanie J HuotDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Neela H YennawarThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-7278-659X
Philip C BevilacquaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-8074-3434
Pennsylvania State University · US

Funding

RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
X-ray instrumentation upgrade for single crystal diffraction and solution small angle scatteringS10OD028589 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2020 to 2020
$600k
Macromolecular X-Ray Crystallography InstrumentS10RR023439 · NCRR · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2007 to 2007
$500k
Wyatt SEC-MALS systemS10OD030490 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2021 to 2021
$273k
NCRR NIH HHS S10 RR023439NIGMS NIH HHS R35 GM127064NIH HHS S10 OD028589NIH HHS S10 OD030490
6 · The paper itself

Abstract

We examined the complex network of interactions among RNA, the metabolome, and divalent Mg

Indexed as

Escherichia coliRNAMetabolomeRNA StabilityThermodynamicsRNA

Identifiers

PMID36306436
PMCPMC9669196
OpenAlexW4307582690

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.