Evidence map›Paper›PMID 36311043›Full record

ArticleBioactive materials2023

Injectable bone marrow microniches by co-culture of HSPCs with MSCs in 3D microscaffolds promote hematopoietic reconstitution from acute lethal radiation.

Haiwei Liang, Yanxiao Ao, Wenjing Li, Kaini Liang, Baixue Tang, Junyang Li, Jianwei Wang, Xiaoyu Zhu, Yanan Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haiwei LiangDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Yanxiao AoDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Wenjing LiDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Kaini LiangDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Baixue TangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Junyang LiDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Jianwei WangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Xiaoyu ZhuDepartment of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Yanan DuDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking, Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic syndrome of acute radiation syndrome (h-ARS) is an acute illness resulted from the damage of bone marrow (BM) microenvironment after exposure to radiation. Currently, the clinical management of h-ARS is limited to medication-assisted treatment, while there is still no specific therapy for the hematopoietic injury from high-dose radiation exposure. Our study aimed to assemble biomimetic three-dimensional (3D) BM microniches by co-culture of hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stem cells (MSCs) in porous, injectable and viscoelastic microscaffolds

Indexed as

3D microscaffoldsBone marrowHematopoietic stem cellsHematopoietic syndrome of acute radiation syndromeMesenchymal stem cells

Identifiers

PMID36311043
PMCPMC9593104

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.