Observational studyCirculation2022
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Open access · hybridAbstract readObservational Study
In one paragraph
Observational study in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Cardiovascular and renal effects of SGLT2 inhibitor initiation in acute heart failure: a meta-analysis of randomized controlled trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Pooled it
- Association of blood urea nitrogen to high-density lipoprotein ratio with all-cause and cardiovascular mortality in individuals with mildly reduced eGFR.Clinics (Sao Paulo, Brazil) · 2026Article
- Article
- The Association Between Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Severity.Reviews in cardiovascular medicine · 2026Article
- Development and validation of a machine learning-based predictive model for new-onset atrial fibrillation after CABG.Frontiers in cardiovascular medicine · 2026Article
- Myocardial fibrosis and tissue alterations predict cardiovascular outcomes in chronic kidney disease-a prospective virtual twin study design using large-scale population database.Frontiers in cardiovascular medicine · 2026Article
- A systematic review and meta-analysis of the efficacy of addition and reduction of Shixiao powder in the treatment of coronary heart disease.Frontiers in cardiovascular medicine · 2026Review
- Metabolic Cardiovascular Renal Disease (Met-CVRD): A New Nomenclature.Diabetes/metabolism research and reviews · 2025Review
- Sex-specific effects of mild kidney dysfunction on vascular function in midlife and older adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- High-density lipoprotein cholesterol, particles and subspecies and the risk of chronic kidney disease: The PREVEND prospective study.Lipids in health and disease · 2025Article
- Association of Epicardial Adipose Tissue with Novel Inflammation and Heart Failure Biomarkers in Type 2 Diabetes Patients: Effect of Metabolic Control.Journal of clinical medicine · 2025Article
- Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson's disease.Scientific reports · 2025Article
- Association of chronic kidney disease and cardiovascular disease risk with all-cause mortality: an interaction, joint and mediation analysis in Chinese adults.BMC public health · 2025Article
- Cardiovascular-kidney-metabolic syndrome modifies smoking-related risk for cardiovascular diseases: findings from an observational cohort study in UK Biobank.BMC public health · 2025Observational
- Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep-Breathing Monitoring Index.Clinical and translational science · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Dose-dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset.European journal of clinical investigation · 2025Article
- Cerebral blood flow following successful living kidney transplantation: the VINTAGE study.Clinical kidney journal · 2025Article
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- IBS May Have a Causal Effect on Increased Tryptophan Metabolites Levels: Insights from a Bidirectional Two-Sample Mendelian Randomization Study.International journal of tryptophan research : IJTR · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
114 authors at 20 institutions in 20 countries.
Liam Gaziano *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Luanluan Sun *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Matthew Arnold *
Steven BellMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).ORCID 0000-0001-6774-3149
Kelly ChoDivision of Aging (K.C., S.P., J.P.C. J.M.G.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Stephen K KaptogeMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Rebecca J SongDepartment of Epidemiology, Boston University School of Public Health, MA (R.J.S.).
Stephen BurgessMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Daniel C PosnerMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).ORCID 0000-0002-3056-6924
Katja MosconiMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine (C.R.-C., E.A.A.), Vanderbilt University Medical Center, Nashville, TN.
Amy M MasonBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0002-8019-0777
Thomas R BoltonBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Ran TaoDepartment of Biostatistics (R. Tao), Vanderbilt University Medical Center, Nashville, TN.
Elias AllaraBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0002-1634-8330
Petra SchubertMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Lingyan ChenBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
James R StaleyBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Natalie StaplinMedical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit (N.S., C.B.), Nuffield Department of Population Health, University of Oxford, UK.ORCID 0000-0003-4482-4418
Servet AltayDepartment of Cardiology, Trakya University School of Medicine, Edirne, Turkey (S.A.).
Pilar AmianoMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain (P.A.).
Volker ArndtDivision of Clinical Epidemiology and Aging Research (V.A.), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
Johan ÄrnlövORCID 0000-0002-6933-4637
Elizabeth L M BarrWellbeing & Preventable Chronic Diseases (WPCD) Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia (E.L.M.B.).ORCID 0000-0003-4284-1716
Cecilia BjörkelundMedical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit (N.S., C.B.), Nuffield Department of Population Health, University of Oxford, UK.
Jolanda M A BoerNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (J.M.A.B., W.M.M.V.).ORCID 0000-0002-9714-4304
Hermann BrennerDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden (J.A., H.B.).ORCID 0000-0002-6129-1572
Edoardo CasigliaStudium Patavinum (E.C.), University of Padua, Italy.ORCID 0000-0002-0003-3289
Paolo ChiodiniDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy (P.C.).ORCID 0000-0003-0139-2264
Jackie A CooperWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, UK (J.A.C.).
Josef CoreshJohns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.C.).ORCID 0000-0002-4598-0669
Mary CushmanLarner College of Medicine, The University of Vermont, Burlington (M.C.).ORCID 0000-0002-7871-6143
Rachel DanknerThe Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel (R.D.).
Karina W DavidsonFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, NY (R.D., K.W.D.).ORCID 0000-0002-9162-477X
Renate T de JonghAmsterdam University Medical Centers, VUMC, the Netherlands (R.T.d.J.).ORCID 0000-0001-8414-3938
Chiara DonfrancescoDepartment of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy (C.D., L. Palmer).
Gunnar EngströmDepartment of Clinical Sciences, Malmö, Lund University, Sweden (G.E., O.M.).ORCID 0000-0002-8618-9152
Heinz FreislingInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (H.F., E.W.).
Agustín Gómez de la CámaraCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (P.A., A.G.d.l.C., D.P., C. Santiuste).ORCID 0000-0001-6827-6319
Vilmundur GudnasonFaculty of Medicine, University of Iceland, Reykjavik, Iceland and Icelandic Heart Association, Kopavogur, Iceland (V.G.).ORCID 0000-0001-5696-0084
Graeme J HankeyMedical School Faculty of Health & Medical Sciences, The University of Western Australia, Perth, WA, Australia (G.J.H.).ORCID 0000-0002-6044-7328
Per-Olof HanssonInstitute of Medicine, Department of Molecular and Clinical Medicine (P.-O.H., A.R.), Sahlgrenska Academy, University of Gothenburg, Sweden.ORCID 0000-0001-6323-0506
Alicia K HeathSchool of Public Health (A.K.H., I.T., E.R.), Imperial College London, UK.ORCID 0000-0001-6517-1300
Ewout J HoornDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, the Netherlands (E.J.H.).ORCID 0000-0002-8738-3571
Hironori ImanoPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan (H.I.).ORCID 0000-0002-6661-4254
Simerjot K JassalDepartment of Cancer Epidemiology (S.K.J., R.K., V.K.), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudolf KaaksDepartment of Cancer Epidemiology (S.K.J., R.K., V.K.), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Verena KatzkeDepartment of Cancer Epidemiology (S.K.J., R.K., V.K.), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6509-6555
Jussi KauhanenUniversity of Eastern Finland (UEF), Kuopio, Finland (J.K.).
Stefan KiechlDepartment of Neurology & Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria (S.K.).ORCID 0000-0002-9836-2514
Wolfgang KoenigInstitute of Epidemiology and Medical Biometry, University of Ulm, Germany (W.K.).ORCID 0000-0002-2064-9603
Richard A KronmalSchool of Public Health, University of Washington, Seattle (R.A.K.).ORCID 0000-0002-9897-7076
Cecilie KyrøDanish Cancer Society Research Center, Copenhagen, Denmark (C.K., A.T.).ORCID 0000-0002-9083-8960
Deborah A LawlorMedical Research Council Integrative Epidemiology Unit, University of Bristol, UK (D.A.L.).
Börje LjungbergDepartment of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Sweden (B.L.).ORCID 0000-0002-4121-3753
Conor MacDonaldUniversity Paris-Saclay, UVSQ, Inserm, Villejuif, France (C. MacDonald).ORCID 0000-0002-4989-803X
Giovanna MasalaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (G.M.).ORCID 0000-0002-5758-9069
Christa MeisingerHelmholtz Zentrum München, Munich, Germany (C. Meisinger).
Olle MelanderDepartment of Clinical Sciences, Malmö, Lund University, Sweden (G.E., O.M.).
Conchi Moreno IribasNavarra Public Health Institute, IdiSNA, Pamplona, Spain (C.M.I.).
Toshiharu NinomiyaGraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T.N.).ORCID 0000-0003-1345-9032
Dorothea NitschLondon School of Hygiene & Tropical Medicine, UK (D.N.).
Børge G NordestgaardHerlev and Gentofte Hospital (B.G.N.), Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-1954-7220
Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands (C.O.-M., Y.T.v.d.S., W.M.M.V.).ORCID 0000-0002-2360-913X
Luigi PalmieriORCID 0000-0002-4298-2642
Dafina PetrovaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (P.A., A.G.d.l.C., D.P., C. Santiuste).
Jose Ramón Quirós GarciaConsejería de Sanidad del Principado de Asturias Oviedo, Asturias, Spain (J.R.Q.G.).
Annika RosengrenInstitute of Medicine, Department of Molecular and Clinical Medicine (P.-O.H., A.R.), Sahlgrenska Academy, University of Gothenburg, Sweden.ORCID 0000-0002-5409-6605
Carlotta SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (C. Sacerdote).
Masaru SakuraiDepartment of Social and Environmental Medicine, Kanazawa Medical University, Uchinada, Japan (M.S.).
Carmen SantiusteCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (P.A., A.G.d.l.C., D.P., C. Santiuste).
Matthias B SchulzeGerman Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (M.B.S.).ORCID 0000-0002-0830-5277
Sabina SieriFondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy (S.S.).ORCID 0000-0001-5201-172X
Johan SundströmDepartment of Medical Sciences, Uppsala University, Sweden (J.S.).ORCID 0000-0003-2247-8454
Valérie TikhonoffDepartment of Medicine (V.T.), University of Padua, Italy.ORCID 0000-0001-7846-0101
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark (C.K., A.T.).
Tammy TongCancer Epidemiology Unit (T.T.), Nuffield Department of Population Health, University of Oxford, UK.ORCID 0000-0002-0284-8959
Rosario TuminoHyblean Association for Epidemiological Reserach AIRE - ONLUS, Ragusa, Italy (R.T.).
Ioanna TzoulakiSchool of Public Health (A.K.H., I.T., E.R.), Imperial College London, UK.ORCID 0000-0002-4275-9328
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands (C.O.-M., Y.T.v.d.S., W.M.M.V.).ORCID 0000-0002-4605-435X
W M Monique VerschurenNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (J.M.A.B., W.M.M.V.).
Henry VölzkeUniversitätsmedizin Greifswald, Institut für Community Medicine, Abteilung SHIP/ Klinisch-Epidemiologische Forschung, Germany (H.V.).
Robert B WallaceCollege of Public Health, University of Iowa (R.B.W.).
S Goya WannametheeUniversity College London, UK (S.G.W.).ORCID 0000-0001-9484-9977
Elisabete WeiderpassInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (H.F., E.W.).ORCID 0000-0003-2237-0128
Peter WilleitBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0002-1866-7159
Mark WoodwardThe George Institute for Global Health, Camperdown, NSW, Australia (M.W.).ORCID 0000-0001-9800-5296
Kazumasa YamagishiDepartment of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Japan (K.Y.).ORCID 0000-0003-3301-5519
Raul Zamora-RosUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat (Barcelona), Spain (R.Z.-R.).ORCID 0000-0002-6236-6804
Elvis A AkwoDivision of Nephrology, Department of Medicine (C.R.-C., E.A.A.), Vanderbilt University Medical Center, Nashville, TN.
Saiju PyarajanDivision of Aging (K.C., S.P., J.P.C. J.M.G.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
David R GagnonDepartment of Biostatistics, Boston University School of Public Health, MA (D.R.G.).ORCID 0000-0002-6367-3179
Philip S TsaoVA Pal Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto Health Care System, CA (P.S.T.).ORCID 0000-0001-7274-9318
Sumitra MuralidharOffice of Research and Development, Veterans Health Administration, Washington, DC (S.M.).
Todd L EdwardsDepartment of Veterans Affairs, Tennessee Valley Health Care System, Vanderbilt University, Nashville (T.L.E.).ORCID 0000-0003-4318-6119
Scott M DamrauerDepartment of Surgery, Corporal Michael Crescenz VA Medical Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.D.).ORCID 0000-0001-8009-1632
Jacob JosephMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).ORCID 0000-0002-7279-4896
Lisa PennellsBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0002-8594-3061
Peter W F WilsonInternal Medicine, VA Atlanta Healthcare System, Decatur, GA (P.W.F.W.).
Seamus HarrisonBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Thomas A GazianoDivision of Cardiovascular Medicine (J.J., T.A.G.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-5985-345X
Michael InouyeBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Colin BaigentInstitute of Medicine, School of Public Health and Community Medicine (C.B.), Sahlgrenska Academy, University of Gothenburg, Sweden.
Juan P CasasMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
Claudia LangenbergMRC Epidemiology Unit, School of Clinical Medicine (C.L., N.W.), University of Cambridge, UK.ORCID 0000-0002-5017-7344
Nick WarehamMRC Epidemiology Unit, School of Clinical Medicine (C.L., N.W.), University of Cambridge, UK.ORCID 0000-0003-1422-2993
Elio RiboliThe George Institute for Global Health (M.W.), Imperial College London, UK.
J Michael Gaziano *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA (L.G., K.C., R.J.S., D.C.P., P.S., J.J., J.P.C., J.M.G.).
John Danesh *BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Adriana M Hung *Division of Nephrology & Hypertension, Department of Medicine, Tennessee Valley Health Care System and Vanderbilt University Medical Center, Nashville (A.M.H.).ORCID 0000-0002-3203-1608
Adam S Butterworth *BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0002-6915-9015
Angela M Wood *BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Emanuele Di Angelantonio *BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).ORCID 0000-0001-8776-6719
Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program
MACOM (United States) · USBrigham and Women's Hospital · USGerman Cancer Research Center · DEUniversity of Padua · ITVA Boston Healthcare System · USEmory Healthcare · USInnsbruck Medical University · ATMalmö University · SEUniversity Medical Center Utrecht · NLVanderbilt University Medical Center · USBoston University · USCentre international de recherche sur le cancer · FRDanish Cancer Society · DKFeinstein Institute for Medical Research · USGoethe-Institute United Kingdom · GBHelmholtz Zentrum München · DEHuman Technopole · ITIstituto Superiore di Sanità · ITPopulation Council · INPublic Health England · GB
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MPrecision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–BLRD VA I01 BX004821British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/13/16/30528British Heart Foundation RG/18/13/33946British Heart Foundation RG/19/4/34452Cancer Research UK 14136CSRD VA IK2 CX001780Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_U137686849Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00017/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12026/6Medical Research Council MR/L003120/1NIEHS NIH HHS P30 ES005605Wellcome Trust 204623/Z/16/ZWorld Health Organization 001
Abstract
backgroundEnd-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.
methodsObservational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.
resultsThere were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min
conclusionsIn people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
Indexed as
Cardiovascular DiseasesCoronary DiseaseDiabetes MellitusStrokeHumansKidneyMendelian Randomization AnalysisProspective StudiesRisk Factorscardiovascular diseasescoronary diseasekidney diseasesstroke
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.