Evidence map›Paper›PMID 36314550›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2022

What's Old and New in Tuberculosis Vaccines for Children.

Lisa M Cranmer, Mark F Cotton, Cheryl L Day, Elisa Nemes

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Challenges in developing new tuberculosis vaccines.Memorias do Instituto Oswaldo Cruz · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lisa M CranmerDepartment of Pediatrics, Division of Pediatric Infectious Disease, Emory School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-6938-9195
Mark F CottonDepartment of Pediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa.ORCID 0000-0003-2559-6034
Cheryl L DayDepartment of Microbiology & Immunology, Emory School of Medicine, Atlanta, Georgia, USA.
Elisa NemesSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-1662-4961
Emory University · USStellenbosch University · ZAUniversity of Cape Town · ZA

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
The role of antibodies in infant TB preventionK23AI143479 · NIAID · EMORY UNIVERSITY · PI CRANMER, LISA M · 2019 to 2023
$950k
NCATS NIH HHS UL1 TR002378NIAID NIH HHS K23 AI143479NIAID NIH HHS P30 AI168386NIH HHS K23AI143479
6 · The paper itself

Abstract

Tuberculosis (TB) is a leading cause of global child mortality. Until the turn of the 21st century, Mycobacterium bovis bacille Calmette-Guerin (BCG) was the only vaccine to prevent TB. The pediatric TB vaccine pipeline has advanced in the past decade to include the evaluation of novel whole cell vaccines to replace infant BCG and investigation of subunit and whole cell vaccines to boost TB immunity during adolescence. We describe the history of BCG, current TB vaccine candidates in clinical trials, and the challenges and opportunities for future TB vaccine research in children. Children are a critical target population for TB vaccines, and expansion of the pediatric TB vaccine pipeline is urgently needed to end the TB pandemic.

Indexed as

Mycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis VaccinesBCG VaccineChildHumansBCG VaccineTuberculosis Vaccineschildtuberculosisvaccine

Identifiers

PMID36314550
PMCPMC9620432
OpenAlexW4307890599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.