ArticleClinical oral investigations2023
Immune markers and microbial factors are related with periodontitis severity in people with HIV.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.World journal of virology · 2024Review
- Periodontal health in a large cohort of Ugandans living with HIV: a cross-sectional study.BMC oral health · 2024Article
- Men with HIV have increased alveolar bone loss.BMC oral health · 2024Article
- Periodontal health in a large cohort of Ugandansliving with HIV: A cross-sectional study.Research square · 2024Article
- Men with HIV Have Increased Alveolar Bone Loss.Research square · 2024Article
- Article
- Factors Associated with Periodontitis in Patients with and without HIV.International journal of dentistry · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe objective of the study is to assess systemic immune markers and microbial factors related to periodontitis severity in people living with HIV.
methodsEighty people living with HIV (PLWH), who exhibited in the last two viral load measurements < 40 copies/mL, underwent full-mouth periodontal examinations and sub-gingival plaque sampling. Periodontitis was classified according to the CDC-AAP case definition. Inflammation, immune-activation, and immunosenescence markers were assessed, microbiological analyses were performed, and oral care routines and HIV characteristics were noted.
resultsFrom our group of PLWH, 42.5% and 57.5% suffered from moderate and severe periodontitis, respectively. Oral care habits did not differ between PLWH with moderate and severe periodontitis. Bacterial subgingival plaque loads were higher, and Porphyromonas gingivalis was more prevalent in PLWH with severe periodontitis than with moderate periodontitis (53% vs 7%, respectively). Mean C-reactive protein levels [CRP, 1.6 mg/L versus 0.8 mg/L, p = 0.020] and percentages of senescent CD28-CD57 + CD8 + T-cells in peripheral blood [16.5 versus 8.9, p = 0.035] were higher with severe periodontitis. Infection duration, CD4 count, CD4/CD8 ratio and type of antiretroviral therapy did not differ between both groups.
conclusionsPeriodontitis severity is related to increased prevalence of Porphyromonas gingivalis, elevated CRP levels, and higher frequencies of circulating CD8 + senescent cells in PLWH.
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Registered trials
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