Evidence map›Paper›PMID 36320886›Full record

ArticleRSC chemical biology2022

A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging.

Antonio Fernandez, Nicola Kielland, Ashraff Makda, Neil O Carragher, M Carmen González-García, Laura Espinar-Barranco, Juan A González-Vera, Angel Orte, Rodolfo Lavilla, Marc Vendrell

Abstract read
In one paragraph

Article in RSC chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Identifying STEDable BFMolecules (Basel, Switzerland) · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonio FernandezCentre for Inflammation Research, The University of Edinburgh Edinburgh UK marc.vendrell@ed.ac.uk.ORCID https://orcid.org/0000-0001-9816-8482
Nicola KiellandCentre for Inflammation Research, The University of Edinburgh Edinburgh UK marc.vendrell@ed.ac.uk.
Ashraff MakdaInstitute of Genetics and Cancer, The University of Edinburgh Edinburgh UK.
Neil O CarragherInstitute of Genetics and Cancer, The University of Edinburgh Edinburgh UK.
M Carmen González-GarcíaNanoscopy-UGR Laboratory, Facultad de Farmacia, Universidad de Granada Granada Spain.ORCID https://orcid.org/0000-0001-6128-0884
Laura Espinar-BarrancoNanoscopy-UGR Laboratory, Facultad de Farmacia, Universidad de Granada Granada Spain.
Juan A González-VeraNanoscopy-UGR Laboratory, Facultad de Farmacia, Universidad de Granada Granada Spain.ORCID https://orcid.org/0000-0002-8199-1330
Angel OrteNanoscopy-UGR Laboratory, Facultad de Farmacia, Universidad de Granada Granada Spain.ORCID https://orcid.org/0000-0003-1905-4183
Rodolfo LavillaLaboratory of Medicinal Chemistry, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of Barcelona Spain.ORCID https://orcid.org/0000-0002-5006-9917
Marc VendrellCentre for Inflammation Research, The University of Edinburgh Edinburgh UK marc.vendrell@ed.ac.uk.ORCID https://orcid.org/0000-0002-5392-9740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane.

Identifiers

PMID36320886
PMCPMC9533399

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.